Multifocal motor neuropathy is an immune mediated disease presenting with multifocal muscle weakness and conduction block. IgM auto-antibodies against the ganglioside GM1 are detectable in about 50% of the patients. Auto-antibodies against the paranodal proteins contactin-1 and neurofascin-155 and the nodal protein neurofascin-186 have been detected in subgroups of patients with chronic inflamm...

DiGeorge syndrome (DGS) is characterized by aplasia or hypoplasia of the thymus and parathyroid glands, cardiac defects and anomaly face. This syndrome is usually associated with hypocalcemia resulting from hypoparathyroidism. In most cases the initial symptom is tetany caused by hypocalcemia within 24-48 hours after birth, with symptoms by immune abnormality appearing later. We report a woman ...

zataria multiflora essential oil possesses immunomodulatory effects and the present study investigatesits effect on immune responses to live newcastle disease (nd) vaccines and faecal shedding period ofvaccine strain virus in chickens. one hundred and eighty chickens from both sexes were divided into 6 equalgroups: group 1: unvaccinated, group 2: vaccinated (b1 vaccine followed by la sota 10 da...

Atopic Dermatitis (AD) is a common chronic skin disease with repeated eczema and pruritus. Excessive immune response to foreign antigens thought be one of the causes disease. Recently, involvement autoimmune abnormalities has also been reported in small number cases. However, relationship between auto-Abs AD remains largely unknown. Currently, we have developed Hupex, comprehensive transcriptom...

Hepatotoxicity disorders are relatively common in patients with inflammatory bowel disease that includesulcerative colitis and Crohn’s disease. Abnormal serum liver functions tests can develop during treatment with(TNF-?) blocking agents, such as, Infliximab. The aim of this review is to clarify the role infliximab thedevelopment enzyme abnormalities most presentationof -associated injury a hep...

Abstract Neutralizing auto-antibodies (auto-Abs) that target type I interferons (IFN), a group of cytokines induce innate immune responses upon viral infection, are found within approximately 10–20% patients with critical COVID-19. We sought to determine if neutralizing IFN auto-Abs contribute severe COVID-19 in the Military Health System (MHS). The Epidemiology, Immunology, and Clinical Charac...

Behçet's disease (BD), also known as the Silk Road disease, is a multisystemic and rare inflammatory disorder primarily prevalent in populations along the Mediterranean Sea. Today, BD is defined as a crossroad between autoimmune and auto-inflammatory syndromes. Variety of syndromes including mucocutaneous manifestations such as oral and genital ulcers, papulopustular lesions and erythema nodosu...

the factors such as disease can disrupt homeostasis, resulting in perturbations of endogenous biochemicals that are involved in key metabolic profiles. metabonomics is useful technique to quantitative description of endogenous metabolites present in a biological sample such as urine, plasma and tissue. high resolution 1 h nuclear magnetic resonance (nmr)-based metabonomics is a technique used t...

Introduction While there are well established associations between ulcerative colitis and chronic liver diseases, between active chronic hepatitis and thyroid disease, and between ulcerative colitis and blood and tissue eosinophilia, a patient in whom all these features were manifested has not hitherto been described. Although it is possible that she had two or more unrelated conditions, it is ...

Introduction While there are well established associations between ulcerative colitis and chronic liver diseases, between active chronic hepatitis and thyroid disease, and between ulcerative colitis and blood and tissue eosinophilia, a patient in whom all these features were manifested has not hitherto been described. Although it is possible that she had two or more unrelated conditions, it is ...