Objectives: The purpose of this study was to introduce the autologous gastroepiploic artery (GEA) as arterial bypass graft for peripheral revascularization. We compared the development of intimal hyperplasia and nitric oxide (NO) capacity in GEA and internal jugular vein (IJV) implanted as peripheral grafts. Materials and methods: In pigs the GEA was implanted into the right peripheral circulat...

Abstract Background We sought to review current applications of fascia lata autografts and update the original collection uses proposed almost a century ago, thereby revealing full extent available contemporary reconstructive surgeon. Method A comprehensive literature search peer-reviewed articles listed within PubMed Medline was performed. Results The properties autologous grafts are presented...

rosthetic arterial grafts constructed from expanded polytetrafluoroethylene (ePTFE) have been used for many years as an alternative to autologous vein grafts for lower extremity bypass. When anastomosed above the knee, their performance is similar to that of autologous vein for up to 2 years after operation, thereafter they are associated with a significantly higher failure rate.1 When anastomo...

Induced pluripotent stem cells (iPSCs) provide the potential for autologous transplantation using cells derived from a patient's own cells. However, the immunogenicity of iPSCs or their derivatives has been a matter of controversy, and up to now there has been no direct comparison of autologous and allogeneic transplantation in the brains of humans or nonhuman primates. Here, using nonhuman pri...

Effective cellularization is a key approach to prevent small-caliber (<4 mm) tissue-engineered vascular graft (TEVG) failure and maintain patency and contractility following implantation. To achieve this goal, however, improved biomimicking designs and/or relatively long production times (typically several months) are required. We previously reported on porcine carotid artery decellularization ...

bone has a capability to repair itself when it is fractured. repair involves the generation of intermediatetissues, such as fibrous connective tissue, cartilage and woven bone, before final bone healing can occur. theprocess of cartilage-to-bone transition (cbt) is a key for the achievement of rigid bone healing duringfracture repair. we tested this potential for elastic cartilage using a long ...

background cartilage tissue has limited regenerative capacity and the management of cartilage defects has always been a challenging issue. platelet-rich plasma (prp) has been recently been used to improve healing of cartilage defects. in the present experiment, we aimed to investigate the effects of prp on regeneration capacity as well as survival of the cartilage grafts in a rabbit model. meth...

The beneficial effect upon osteogenesis of impregnating allograft (homograft) bone with autologous red marrow has been reported in several publications (Burwell 1964, 1966; Matthes, Gibel, Wildner and Marx 1968; Boyne 1970; Nade 1970). This paper reports a study of the fate of sheep and calf cancellous bone grafts impregnated with autologous red marrow and implanted into rats as composite xenog...

*Correspondence: Kibret Mequanint , Department of Chemical and Biochemical Engineering, The University of Western Ontario, 1151 Richmond Street, London, ON N6A 5B9, Canada e-mail: [email protected] With the growing need for coronary revascularizations globally, several strategies to restore blood flow to the heart have been explored. Bypassing the atherosclerotic coronary arteries with autologous...

A tissue-engineered small-diameter arterial graft would be of benefit to patients requiring vascular reconstructive procedures. Our objective was to produce a tissue-engineered vascular graft with a high patency rate that could withstand arterial pressures. Rat arteries were acellularized with a series of detergent solutions, recellularized by incubation with a primary culture of endothelial ce...