Azathioprine hepatotoxicity has been described mainly in renal transplant recipients. Most reported cases are related to lesions of the venous system of the liver: peliosis hepatis, veno-occlusive disease of the liver, perisinusoidal fibrosis, and nodular regenerative hyperplasia of the liver. The most common clinical manifestation of these hepatic vascular lesions is portal hypertension. We pr...

We report here a case of Crohn's disease in which there is strong circumstantial evidence that azathioprine precipitated the development of an intraabdominal abscess on two separate occasions. On both occasions, the abscess developed within a few weeks of the patient starting azathioprine, and complete healing occurred on stopping azathioprine. The patient had never previously had this complica...

BACKGROUND Azathioprine is a useful agent in the management of inflammatory bowel disease. Its use is limited by its side-effect profile. Marrow toxicity occurs in approximately 3.2% of patients and is known to be associated with diminished thiopurine methyltransferase enzyme activity resulting from genetic polymorphisms. AIM To evaluate the cost-effectiveness of screening for thiopurine meth...

BACKGROUND Azathioprine is efficacious in the treatment of severe childhood atopic dermatitis; however, robust data on adverse effects in this population are lacking. OBJECTIVE We sought to assess adverse effects of azathioprine treatment in a pediatric atopic dermatitis cohort, and make recommendations for monitoring based on these data. METHODS Blood test results for all 82 children presc...

BACKGROUND Parthenium hysterophorus is the commonest cause of airborne contact dermatitis in India. Azathioprine has been shown to be effective and safe in parthenium dermatitis, but there are no reports of comparison of steroids and azathioprine in this condition. AIMS To study the therapeutic efficacy of azathioprine versus betamethasone in patients having contact dermatitis to parthenium a...

BACKGROUND In a small number of cases of childhood atopic dermatitis, topical therapy is ineffective, necessitating prolonged use of systemic immunosuppressants. Over the last few years, a better understanding of the metabolic pathways involved in azathioprine breakdown has enabled us to use this drug more safely. In this study, we evaluated the toxicity of azathioprine treatment adjusted to th...

Cyclosporin and azathioprine are immunosuppressive drugs, used widely in kidney transplant patients. A significant association between immunosuppressive therapy and multiple warts was described several years ago. There are also some reports of sebaceous gland hyperplasia in kidney transplant patients receiving cyclosporin. We report herein a 57-year-old woman who developed multiple warts on her...

Dear Editor, Azathioprine, a steroid sparing immunosuppressant, is used in organ transplantation and various immunological diseases like pemphigus vulgaris, pemphigus foliaceous, vitiligo, lichen planus, and alopecia areata. Anagen effluvium (AE) is the abrupt loss of hairs in their growing phase most commonly due to chemotherapy and radiation 1. Azathioprine can cause AE in association with my...

background: erythrocyte sedimentation rate (esr) is one of the predictors of improvement in handling rheumatoid arthritis. this study was designed to define and compare the time of achieving normal esr and also the percentage for the normalization of this marker at several points of time in two different combination therapies.methods: fifty-two rheumatoid arthritis patients randomly received me...