LGK974 is a potent Wingless-related integration site inhibitor at Phase II of clinical trial. However, little known about its role and the underlying mechanisms in human hepatocellular carcinoma. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide colony formation assays were used to determine cytotoxicity on liver cancer cell lines. Flow cytometry assay was performed examine apoptosis...

Patients with cytokine receptor-like factor 2 rearranged (CRLF2-re) subgroup Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like B-ALL) have a high relapse rate and poor clinical outcomes. CRFL2-re Ph-like B-ALL is characterized by heightened activation of multiple signaling pathways, including the JAK/STAT and PI3K/AKT/mTOR pathways. We hypothesized that the combined inhi...

Clostridium difficile toxin A (TcdA) and toxin B (TcdB), C. sordellii lethal toxin (TcsL) and C. novyi alpha-toxin (TcnA) are important pathogenicity factors, which represent the family of the clostridial glucosylating toxins (CGTs). Toxin A and B are associated with antibiotic-associated diarrhea and pseudomembraneous colitis. Lethal toxin is involved in toxic shock syndrome after abortion and...

There are multiple mechanisms by which cells evade TGF-b–mediated growth inhibitory effects. In this report, we describe a novel mechanism by which cells become resistant to TGF-b–mediated growth suppression. Although having all the components of the TGF-b signaling pathway, different cell lines, RL, HaCaT, and BJAB, have different sensitivities toward TGF-b–induced growth suppression. The TGF-...

There are multiple mechanisms by which cells evade TGF-b–mediated growth inhibitory effects. In this report, we describe a novel mechanism by which cells become resistant to TGF-b–mediated growth suppression. Although having all the components of the TGF-b signaling pathway, different cell lines, RL, HaCaT, and BJAB, have different sensitivities toward TGF-b–induced growth suppression. The TGF-...