نتایج جستجو برای: b7 h4

تعداد نتایج: 9051  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Kimberly A Hofmeyer Anjana Ray Xingxing Zang

T lymphocytes of adaptive immunity provide vertebrates with the ability to survey for and respond specifically to an incredible diversity of antigens, whether foreign or native. Appropriate T cell response is required to eradicate pathogens, whereas abnormal T cell function could lead to autoimmune diseases, cancer, and transplantation rejection. The outcome of T cell engagement of antigen is d...

Journal: :Journal of immunology 2012
Kimberly A Hofmeyer Lisa Scandiuzzi Kaya Ghosh Liise-Anne Pirofski Xingxing Zang

B7x (B7-H4 or B7S1), a member of the B7 family, inhibits in vitro T cell proliferation and cytokine production by binding to an unidentified receptor on activated T cells, but its in vivo function remains largely unclear. We show that B7x protein was expressed in epithelial cells of the lung, but not in lymphoid tissues. To investigate the role of B7x in the lung, we determined the susceptibili...

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