Objectives: This study was done to assess the spread of bad habits among juvenile convicts and determine the motives for use and the consequences of addiction. Methods: This study was descriptive and carried out at the Federal State Healthcare Institution. The study group included 106 adolescents aged 14 to 19 years. Sample selection was based on a multi-stage sampling method. The research too...

Björn Müller-Edenborn, MD, Jürgen Allgeier, MD, Ralph Hartmann, MD, Thomas Zeller, MD, Thomas Arentz, MD From the Department of Cardiology, University Heart Center Freiburg Bad Krozingen, Bad Krozingen, Germany, Department of Electrophysiology, University Heart Center Freiburg Bad Krozingen, Bad Krozingen, Germany, Department of Radiology, University Heart Center Freiburg Bad Krozingen, Bad Kro...

Bad, a proapoptotic member of the Bcl-2 family, is inactivated by phosphorylation, and this loss of activity may contribute to the malignancy of certain types of tumors such as glioblastoma and prostate cancer. To determine whether extracellular Bad can be delivered into cells via cell surface receptor binding and induce apoptosis, we genetically fused the mouse Bad gene to the gene for the tra...

Here we show that LNCaP, which is resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, becomes sensitive to TRAIL after overexpression of full-length, wild-type BAD (BAD WT). TRAIL induces caspase-dependent cleavage of BAD WT that results in generation of a M(r) 15,000 protein. LNCaP stably expressing truncated BAD (tBAD) and cells expressing mutated B...