The BAR (Bin-Amphiphysin-Rvs) domain undergoes dimerization to produce a curved protein structure, which superimposes onto membrane through electrostatic interactions to sense and impart membrane curvature. In some cases, a BAR domain also possesses an amphipathic helix that inserts into the membrane to induce curvature. ACAP1 (Arfgap with Coil coil, Ankyrin repeat, and PH domain protein 1) con...

Members of the Bin/amphiphysin/Rvs (BAR) domain protein superfamily are involved in membrane remodeling in various cellular pathways ranging from endocytic vesicle and T-tubule formation to cell migration and neuromorphogenesis. Membrane curvature induction and stabilization are encoded within the BAR or Fer-CIP4 homology-BAR (F-BAR) domains, alpha-helical coiled coils that dimerize into membra...

I review the arguments for the importance of halo structure in driving galaxy evolution and coupling a galaxy to its environment. We begin with a general discussion of the key dynamics and examples of structure dominated by modes. We find that simulations with large numbers of particles (N ∼> 10 ) are required to resolve the dynamics. Finally, I will describe some new results which demonstrates...

BAR-domains recently took centre stage in science through a report on the crystal structure of this domain in Drosophila Amphiphysin. Though only weakly conserved at the sequence level, the structure of the BAR domain shows striking similarity to the GTPase-binding domain of Arfaptin 2, an effector of Rho- and Arf- GTPases. On the basis of this sequence and structural similarity, these two prot...

This article proposes a method to estimate the axial force in a bar based on local vibration measurements. The method assumes Timoshenko beam theory and in addition accounts for the rotational inertia of the bar and the mass of the sensors. A major advantage of the proposed method is its generality. Assuming at least five sensors along the length of the bar, no information on the connection of ...

A spectrum of membrane curvatures exists within cells, and proteins have evolved different modules to detect, create, and maintain these curvatures. Here we present the crystal structure of one such module found within human FCHo2. This F-BAR (extended FCH) module consists of two F-BAR domains, forming an intrinsically curved all-helical antiparallel dimer with a Kd of 2.5 microM. The module bi...

In this pare, a wideband three-order bandpass filter (BPF) is proposed. The proposed wideband filter is designed using the substrate integrated waveguide (SIW) structure by loading T-shape slots. A BPF with two resonators is formed by etching T-shape slots with different size on the top metal plane of the SIW structure. The filter is investigated with the theory of coupled resonator circuits. T...