OBJECTIVE To review the normal human acid-base physiology and the pathophysiology and management of acid-base disturbances in a two-part presentation. DATA SOURCES Articles and published peer-review abstracts and a review of studies reported from 1990 to 2000 and identified through a MEDLINE search of the English language literature on acid-base balance. SUMMARY OF REVIEW Acid-base disorder...

Background: In patients undergoing surgery, acid-base imbalance during general anesthesia causes disruption in the function of cardiovascular, respiratory, musculoskeletal and the central nervous system. Since the potential complications of acid-base disturbances are serious, we decided to explore these changes and related causes so that prevention and compensation would be feasible. Methods: I...

Often, too little consideration is given to the fluids used in all forms of continuous renal replacement therapy (CRRT). However, errors in fluid prescription, delivery, or creation can be rapidly fatal; in addition, fluid associated expenses can be the overriding cost in continuous renal replacement therapies. While a standard solution is frequently acceptable in most clinical circumstances, s...

We read with great interest the article by Guérin and colleagues, in the November 2010 issue of RESPIRATORY CARE,1 describing analysis of acid-base disorders with the Stewart method versus the conventional approach in patients with chronic respiratory failure in stable or unstable respiratory condition. Unfortunately, we find several aspects of the analysis to be rather misleading. First, accor...

Inhibition of renal prostaglandin synthesis by non-steroidal anti-inflammatory drugs (NSAIDs) causes various electrolyte and acid-base disturbances including sodium retention (edema, hypertension), hyponatremia, hyperkalemia, and decreased renal function. Decreased sodium excretion can result in weight gain, peripheral edema, attenuation of the effects of antihypertensive agents, and rarely agg...

The effects of radiofrequency exposure on the health people living near mobile-phone base stations (MPBSs) have been subject several studies since mid-2000s, with contradictory results. We aimed to investigate association between measured electromagnetic fields (RF-EMF) from MPBSs and presence self-reported non-specific insomnia-like symptoms. A cross-sectional survey conducted 2015 2017 in fiv...