n page 803, Gourlay et al. report the first evidence that the actin cytoskeleton can affect release of reactive oxygen species (ROS) by mitochondria, and thus life span in yeast. Certain mutant Saccharo-myces cerevisiae strains with alleles that reduce actin dynamics possess defective mitochondria. The team O Cells with increased actin dynamics live longer. went on to show that such strains dis...

I diopathic inflammatory bowel disease (IBD) collectively describes ulcerative colitis (UC) and Crohn’s disease (CD). UC is characterised by inflammation limited to the colonic mucosa and collagen deposition only in the submucosa, whereas CD is characterised by transmural, granulomatous inflammation and thickening of the bowel wall as a result of thickening of the muscularis layers and transmur...

The majority of cancer is of surface/cyst epithelial origin. The ovarian surface epithelial cells are organized by a sheet of basement membrane composed mainly of collagen IV and laminin, and it is believed that the basement membrane greatly influences the physiological properties of ovarian surface epithelial cells. Previous studies in our laboratories indicated that loss of the basement membr...

Using an immunoperoxidase procedure, we have examined the distribution of laminin and fibronectin in normal human large intestinal mucosa and in 50 cases of rectal adenocarcinoma for which extensive clinical follow up was available. In normal tissue, laminin staining was largely restricted to basement membranes, including that underlying the epithelial cells, whereas fibronectin was found in bo...