A combination of a literature survey, structure-based virtual screening and synthesis of a small library was performed to identify hits to the potential antimycobacterial drug target, glutamine synthetase. The best inhibitor identified from the literature survey was (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid (4, IC(50) of 610+/-15microM). In the virtual screening 46,400 compounds were docked an...

BACKGROUND Colorectal cancer screening reduces death from colorectal cancer, but screening rates are low. While research has identified barriers to screening from the patient perspective, less research has addressed screening from the physician perspective. METHODS The Washington Comprehensive Cancer Control Partnership conducted a survey of primary care physicians in Washington State to meas...

BACKGROUND Screening and postsymptomatic diagnostic testing are often conflated in cancer screening surveillance research. We examined the error in estimated colorectal cancer screening prevalence due to the conflation of screening and diagnostic testing. METHODS Using data from the 2008 National Health Interview Survey, we compared weighted prevalence estimates of the use of all testing (scr...

This study compared the training and protocols used by two groups of elementary school hearing screeners: one group of school nurses and one group of contractually hired personnel. The participants were asked to complete a survey concerning their training, screening protocols, and opinions on minimal hearing loss (MHL). Results revealed that the school nurses listed more sources of training and...

results there were minor differences in treatment preferences for graves’ disease in pregnancy and tests to monitor antithyroid drugs between endocrinologists and generalists; the major difference being targeted free thyroxin, and also thyroxin, depicted in the upper end of normal range, by the majority of endocrinologist and within the normal range, by generalists. compared to generalists, end...

As part of an epidemiological study of hypertension, an analysis was made of the general practitioner records of all attenders at a screening survey. A blood pressure recording, made before screening, was found in 37-9 per cent of cases. The pressures obtained correlated well with those obtained by the screening unit, though the practitioners' readings tended to be lower. Further cases of hyper...

OBJECTIVE Violence toward others is a serious problem among a subset of military veterans. The authors evaluated the predictive validity of a brief decision support tool to screen veterans for problems with violence and identify potential candidates for a comprehensive risk assessment. METHOD Data on risk factors at an initial wave and on violent behavior at 1-year follow-up were collected in...