نتایج جستجو برای: bed rest
تعداد نتایج: 124989 فیلتر نتایج به سال:
INTRODUCTION Spaceflight has profound effects on the human body. Many of these effects can be induced with head-down bed rest, which has been a useful ground-based analog. With limited resources aboard the International Space Station for human research, the bed rest analog will be a primary platform on which countermeasures will be developed and tested for lunar and Mars mission scenarios. ME...
The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with bone loss induced by bed rest, and testify whether the selected miRNAs could reflect the bone mineral status of human after bed-rest. We analyzed plasma miRNA levels of 16 subjects after 45 days of -6° head-down tilt bed rest, which is a reliable model for the simulation of microgravity. We characterize the...
The metabolic and hemodynamic effects of prolonged bed rest were studied in 6 normal subjects. Bed rest of 2-3 weeks duration produced exaggerated responses of heart rate, cardiac output, stroke volume, and peripheral vascular resistance to 700 tilt. Sympathetic nerve function and catecholamine metabolism were not impaired by bed rest. Pressor responses to infusions of norepinephrine and angiot...
Long-duration bed rest is widely employed to simulate the effects of microgravity on various physiological systems, especially for studies of bone, muscle, and the cardiovascular system. This microgravity analog is also extensively used to develop and test countermeasures to microgravity-altered adaptations to Earth gravity. Initial investigations of bone loss used horizontal bed rest with the ...
Five healthy young men were studied during 24-30 wk of continuous bed rest. During the first 12 wk of bed rest, untreated subjects increased calcium excretion in the urine by 109 mg/day and in the feces by 147 mg/day. The rate of total body calcium loss was 0.5-0.7% per month. Losses of central calcaneus mineral, assessed by gamma ray transmission scanning, occurred at a tenfold higher rate, wh...
Introduction: Coronary angiography is frequently applied for diagnostic purposes in patient with coronary artery disease. There is no consensus about the optimal time for the ambulation on patients following femoral arterial puncture. This study intended to investigate the differences between 6 hours of complete bed rest and 2 hours of complete bed rest for the patients after angiography. Met...
Leg venous hemodynamics [venous distensibility index (VDI), arterial flow index (AFI), half-emptying time (T1/2)], and leg volumes (LV) were assessed by mercury strain-gauge plethysmography with venous occlusion and volometry, respectively, in seven men before, during, and after 42 days of 6 degrees head-down bed rest. Results showed a high increase in VDI up to day 26 of bed rest (+50% vs. con...
Individuals born with low birth weight (LBW) are at risk of developing type 2 diabetes mellitus (T2D), which may be precipitated by physical inactivity. Twenty-two LBW subjects and twenty-three controls were studied before and after bed rest by the hyperinsulinemic euglycemic clamp combined with indirect calorimetry and infusion of stable isotope tracers and preceded by an intravenous glucose t...
a 25-year-old woman (gravida 2, abortion 1) was admitted to ghaem hospital affiliated to mashhad university of medical sciences at 24 th week of gestation. her chief complaint was bloody show. she had a history of incompetent cervix, with premature labor at 22 nd week of gestation. she was hospitalized with 4 cm dilatation and 50% effacement of cervix at 24 th week of gestation. following bed r...
Bed rest decreases mechanically induced myofiber wounding and consequent wound-mediated FGF release.
Using a terrestrial model of spaceflight (i.e., bed rest), we investigated the amount of myofiber wounding and fibroblast growth factor (FGF) release that occurs during unloading. Myofiber wounding was determined by serum levels of the creatine kinase MM (CKMM) isoform before and after bed rest. Serum levels of both acidic FGF (aFGF) and basic FGF were also determined. A second group of subject...
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