The recent article by Wang et al. (2012a) was highly interesting. Interestingly, recent data suggests that Skp2 expression may play a significant role in the etio-pathogenesis of a number of systemic malignancies besides breast carcinomas. For instance, the expression of Skp2 in prostate cancers is decreased by androgens and is mediated via pathways that are dependent on p107 as well as pathway...

Short interspersed elements (SINEs), which are nonautonomous transposable elements, require the transposition machinery of long interspersed elements (LINEs) to mobilize. SINEs are composed of two or more independently originating parts. The 5' region is called the "head" and is derived mainly from small RNAs, and the 3' region ("tail") originates from the 3' region of LINEs and is responsible ...

OBJECTIVE Type 2 diabetes is the most common form of diabetes worldwide. Some of its complications, such as retinopathy and neuropathy, are long-term and protracted, with an unclear etiology. Given this problem, genetic model systems, such as in flies where type 2 diabetes can be modeled and studied, offer distinct advantages. RESEARCH DESIGN AND METHODS We used individual flies in experiment...

Whether or not factors besides hyperphagia influence cellularity of adipose tissue in gold thioglucose (GTG)-treated mice was examined. The animals were treated with GTG (800 mg/kg body weight) or saline as control. Control and one of the GTG-treated groups were given a diet ad libitum and another of the GTG-treated groups was pair-fed to control. In GTG-treated group fed ad libitum, hyperphagi...