The first noncovalent double hydrophilic block copolymer was constructed through inclusion complexation between beta-cyclodextrin and the adamantyl group; it can further self-assemble into two distinctly different micelles in response to pH and temperature in dilute aqueous solution.

We determined the concentration dependence of albumin binding, uptake, and transport in confluent monolayers of cultured rat lung microvascular endothelial cells (RLMVEC). Transport of (125)I-albumin in RLMVEC monolayers occurred at a rate of 7.2 fmol. min(-1). 10(6) cells(-1). Albumin transport was inhibited by cell surface depletion of the 60-kDa albumin-binding glycoprotein gp60 and by disru...

OBJECTIVE HIV-1 particles are enriched with cholesterol; however, the significance of this cholesterol enrichment is unknown. This study examines the structural and functional roles of cholesterol in HIV-1 replication. METHODS Using methyl-beta-cyclodextrin (CD) to remove cholesterol from the HIV-1 envelope, buoyant density and infectivity of the cholesterol-deficient HIV-1 particles were com...

REZUMAT INCORPORATION OF ISOFLAVONOID GENISTEIN IN BETA RAMIFIED CYCLODEXTRINS AN OPTION FOR IMPROVING WATER SOLUBILITY Corina Tiulea Danciu1, Cristina Dehelean2, Codruta M. Soica3, Camelia Peev1, Andrei Motoc4 Isoflavonoid genistein (4’,5,7-trihydroxyisoflavone), the aglicon of heteroside genistin, represent the major active compound from soybean. It is solubile in organic solvents such as DMS...