A 7 year old girl was diagnosed with ALL. She presented only with bleeding in the mouth after reinduction ALL-BFM (BerlinFrankfurt-Munster) 95 chemotherapy. The most prominent lesions were petechiae and 5-10 mm purpuric macules as red spots on her tongue without fever and trauma (Figure 1). Her platelet count was less than 5000/mm3 and her coagulation tests were normal. She responded quickly to...

We establish interior gradient bounds for functions u ∈ W 1 1,loc (Ω) which locally minimize the variational integral J[u, Ω] = ∫ Ω h (|∇u|) dx under the side condition u ≥ Ψ a.e. on Ω with obstacle Ψ being locally Lipschitz. Here h denotes a rather general N-function allowing (p, q)-ellipticity with arbitrary exponents 1 < p ≤ q < ∞. Our arguments are based on ideas developed in [BFM] combined...

It’s been said that if debugging is the process of removing bugs from a program, then programming must be the process of putting them in. Although I don’t personally write bugs (ahem), I understand from others that they can be quite difficult to track down and fix. My personal recommendation is to avoid writing them in the first place; steer clear of popular assembler instruction such as “BFM” ...

Marjolein Blink, Marry M. van den Heuvel-Eibrink, Valerie de Haas, Jan-Henning Klusmann, Henrik Hasle, and C. Michel Zwaan Department of Pediatric Oncology/Hematology, Erasmus MC–Sophia Children’s Hospital Rotterdam, The Netherlands; Dutch Childhood Oncology Group, The Hague, The Netherlands; Department of Pediatric Oncology/Hematology, AML-BFM Study Group, Medical High School, Hannover, German...

Subcutaneous panniculitis-like T-cell lymphoma (SPLTCL) which is similar to lobular panniculitis a subtype of skin that characterized by pleomorphic T cells and benign macrophages. The simultaneous presence hemophagocytic lymphohistiocytosis (HLH) the most important adverse prognostic factor in SPLTCL. SPLTCL rare disease with no well-established standard treatment. We report child HLH, who wer...

The aim of this study was to evaluate the outcomes using the dose-adjusted Berlin-Frankfurt-Munster (BFM-90) regimen without radiotherapy in adolescents and adults with T cell lymphoblastic lymphoma (T-LBL) at Beijing Cancer Hospital. Between March 2004 and December 2013, 57 newly diagnosed T-LBL patients were treated in our center. We retrospectively analyzed their main clinical characteristic...

One hundred ninety-eight children and adolescents were entered in the Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP)-ALL95 study for highrisk acute lymphoblastic leukemia (ALL). Inclusion criteria were poor response to initial prednisone/intrathecal methotrexate (prednisone-poor response [PPR]), resistance to induction therapy, translocation t(9;22), infants with the t(4;11...

Single linear polymer chains in dilute solutions under good solvent conditions are studied by Monte Carlo simulations with the pruned-enriched Rosenbluth method up to the chain length N~O(10(4)). Based on the standard simple cubic lattice model (SCLM) with fixed bond length and the bond fluctuation model (BFM) with bond lengths in a range between 2 and √10, we investigate the conformations of p...