OBJECTIVE To evaluate antiviral activity, safety, and pharmacokinetics of short-term monotherapy with bictegravir (BIC), a novel, potent HIV integrase strand transfer inhibitor (INSTI). DESIGN Phase 1b, randomized, double-blinded, adaptive, sequential cohort, placebo-controlled study. METHODS HIV-infected adults not taking antiretroviral therapy were randomized to receive BIC (5, 25, 50, or...

Hierarchical clustering of text collections is a key problem in document management and retrieval. In partitional hierarchical clustering, which is more efficient than its agglomerative counterpart, the entire collection is split into clusters and the individual clusters are further split until a heuristically-motivated termination criterion is met. In this paper, we define the BIC-means algori...

In this paper, an approach of dynamic threshold setting via Bayesian Information Criterion (BIC) in HMM training is described. The BIC threshold setting is applied to two important applications. Firstly, it is used to set the thresholds for decision tree based state tying, in place of the conventional approach of using a heuristic constant threshold. Secondly, it is applied to choosing the numb...

Optical bound states in the continuum (BIC) are localized states with energy lying above the light line and having infinite lifetime. Any losses taking place in real systems result in transformation of the bound states into resonant states with finite lifetime. In this work, we analyze properties of BIC in CMOS-compatible one-dimensional photonic structure based on siliconon-insulator wafer at ...

A novel approach to the Bayesian Information Criterion (BIC) is introduced. The new criterion redefines the penalty terms of the BIC, such that each parameter is penalized with the effective sample size is trained with. Contrary to Local-BIC, the proposed criterion scores overall clustering hypotheses and therefore is not restricted to hierarchical clustering algorithms. Contrary to Global-BIC,...

This paper presents an improved distance measure for speaker clustering in speaker diarization systems. The proposed phonetic subspace mixture (PSM) model introduces phonetic information to the BIC distance measure. Therefore, the new PSM model-based BIC distance measure can remove the effect of phonetic content on the diarization results. The typical BIC distance measure can be seen as a speci...

PURPOSE Specifically with zygomatic implants, the bone-to-implant contact (BIC) at the zygomatic bone correlates with the survival of the implant because there is little anchorage at the alveolus. The purpose of this retrospective study was to view and measure the BIC of zygomatic implants in the zygomatic bone. MATERIALS AND METHODS The patients in this study received zygomatic implants at a...

Information criteria are an appropriate and widely used tool for solving model selection problems. However, different ways to use them exist, each leading to a more or less precise approximation of the sought model. In this paper, we mainly present two methods of utilisation of information criteria : the classical one which is generally used and an alternative one, more precise but requiring a ...

To determine the number of clusters in the clustering analysis that has a broad range of applied sciences, such as physics, chemistry, biology, engineering, economics etc., many methods have been proposed in the literature. The aim of this paper is to determine the number of clusters of a dataset in a model-based clustering by using an Analytic Hierarchy Process (AHP). In this study, the AHP mo...

Nuclear translocation, driven by the motility apparatus consisting of the cytoplasmic dynein motor and microtubules, is essential for cell migration during embryonic development. Bicaudal-D (Bic-D), an evolutionarily conserved dynein-interacting protein, is required for developmental control of nuclear migration in Drosophila. Nothing is known about the signaling events that coordinate the func...