Hamid Nasri1 Azar Baradaran2 End-stage renal failure often is associated with abnormal bleeding that may represent an important complication of this disorder. The hemorrhagic tendency currently is attributed to altered primary hemostasis, mainly platelet dysfunction. The aim of the present study was to elucidate whether and how in patients, with uremia on hemodialysis, the level of plasma HCO3 ...

Introduction We have shown previously that C-labeled bicarbonate (HCO3 ) can be hyperpolarized using Dynamic Nuclear Polarisation (DNP) and that when this is injected in vivo, the enzyme carbonic anhydrase (CA) rapidly interconverts this with carbon dioxide (CO2) [1]. Furthermore, we have also shown that selective saturation of the CO2 signal in vivo will decrease the H CO3 signal in the presen...

Groundwater aquifers as one of the main sources of water supplies are faced with different risks such as level dropping due to lack of precipitation, and natural and non-natural pollutants. Thus, it is extremely necessary to monitor ground water quality. In the present study, the concentration of cations, anions, and some toxic metals was evaluated in 21 rural water supplies in Qorveh plain in ...

Intracellular microelectrode techniques and intracellular pH (pHi) measurements using the fluorescent dye 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF) were employed to characterize an electrogenic bicarbonate transport mechanism at the apical membrane of the frog retinal pigment epithelium (RPE). Reductions in apical concentrations of both [HCO3]o (at constant Pco2 or pHo) or [Na]o c...

PURPOSE To determine whether maintenance of corneal hydration is dependent on bicarbonate ions and whether these ions can be derived from metabolic or exogenous CO2, and to investigate the relationship of transendothelial fluid movement to control of hydration. METHODS The thickness of intact or deepithelialized rabbit corneas was measured while superfused on the endothelial surface with eith...

Heisler (1984, 1986) suggested that fish have a maximum extracellular bicarbonate concentration of about 30mmoll~, which can be attained and used for the compensation of blood acidosis induced during environmental hypercapnia. In contrast, Borjeson (1977) and Dimberg & Hoglund (1987) reported HCO3~ concentrations, analysed using Astrup's tonometric method (Astrup, 1956), of 40—SOmmoll" in venou...

The present in vitro microperfusion study examined apical membrane Na+/H+ antiporter and basolateral membrane Na(HCO3)3 symporter activity in newborn and adult juxtamedullary proximal convoluted tubules. Proton fluxes were determined from the initial rate of change of intracellular pH after a change in the luminal or bathing solution, buffer capacity, and tubular volume of newborn and adult tub...

A 28-year-old female with history of hypothyroidism, Sjögren's Syndrome, and Systemic Lupus Erythematosus (SLE) presented with complaints of severe generalized weakness, muscle pain, nausea, vomiting, and anorexia. Physical examination was unremarkable. Laboratory test showed hypokalemia at 1.6 mmol/l, nonanion metabolic acidosis with HCO3 of 11 mmol/l, random urine pH of 7.0, and urine anion g...

Na+:H+ and Cl-:HCO3- exchange are localized, respectively, to basolateral (blLPM) and canalicular (cLPM) rat liver plasma membranes. To determine whether these exchangers play a role in bile formation, we examined the effect of a choleretic agent, ursodeoxycholate (UDCA), on these exchange mechanisms. 22Na (1 mM) and 36Cl (5 mM) uptake was determined using outwardly directed H+ and HCO3- gradie...