نتایج جستجو برای: bile acid metabolism
تعداد نتایج: 944000 فیلتر نتایج به سال:
Humans and mice differ substantially in their bile acid profiles as mice in addition to cholic acid (CA) predominantly synthesize 6β-hydroxylated muricholic acids (MCAs) whereas humans produces chenodeoxycholic acid (CDCA) and CA as primary bile acids. Identifying the gene performing 6β-hydroxylation would be useful for 'humanizing' the bile acid profile in mice for studies of the interaction b...
Our previous communication (2) reported the metabolism of lithocholic acid-24-W in the rat and the identification of chenodeoxycholic acid, 30(, 6/3-dihydroxy-5@-cholanoic acid, cy-muricholic acid, and P-muricholic acid as metabolites in the bile. Since previous studies (3) have shown that chenodeoxycholic acid is metabolized to QIand P-muricholic acids in the rat, chenodeoxycholic acid is prob...
Although bile acid and bile lipid metabolism have been studied in established cholelithiasis, little is known about them in patients destined to develop gall stones, but in whom the stones have not yet appeared (prestone gall stone disease). After confirmed complete gall stone dissolution and withdrawal of treatment, gall stones recur frequently. Before the stones reappear, these patients have ...
Bile acids make up a group of sterol-derived compounds that act as detergents in the intestine to facilitate the digestion and absorption of fats and fat-soluble molecules. In mammalian species, the cholesterol side chain is trimmed to yield C24-sterol derivatives. In other vertebrate species, the hydroxylation of the side chain does not lead to its removal and the products of the biosynthetic ...
Although the physiological roles of the individual bile acid synthetic enzymes have been extensively examined, relatively little is known regarding the function of intracellular bile acid-binding proteins. Male L-FABP (liver fatty-acid-binding protein) gene-ablated mice were used to determine a role for L-FABP, the major liver bile acid-binding protein, in bile acid and biliary cholesterol meta...
During the last decades it has become clear that bile acids not only act as simple fat solubilizers, but additionally represent complex hormonal metabolic integrators. Bile acids activate both nuclear receptors (controlling transcription of genes involved in for example bile acid, cholesterol, and glucose metabolism) and the cell surface G protein-coupled receptor TGR5 (modulating energy expend...
BACKGROUND The dried root of Paeonia lactiflora Pall. (PLP) is a classical Chinese herbal medicine that has been used to treat hepatic disease for 1000s of years. Our previous work suggested that PLP can be used to treat hepatitis with severe cholestasis. This study explored the mechanism by which PLP affects ANIT-induced cholestasis in rats using a metabolomics approach. METHODS The effects ...
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