AIM To analyze time intervals of inflammation and regeneration in a cholestatic rat liver model. METHODS In 36 Lewis rats, divided into six groups of 6 animals (postoperative observation periods: 1, 2, 3, 4, 6, 8 wk), the main bile duct was ligated with two ligatures and observed for the periods mentioned above. For laboratory evaluation, cholestasis parameters (bilirubin, γ-GT), liver cell p...

UNLABELLED Alterations in apical junctional complexes (AJCs) have been reported in genetic or acquired biliary diseases. The vitamin D nuclear receptor (VDR), predominantly expressed in biliary epithelial cells in the liver, has been shown to regulate AJCs. The aim of our study was thus to investigate the role of VDR in the maintenance of bile duct integrity in mice challenged with biliary-type...

background: in some disorders such as diabetes mellitus patients can display depressive symptoms. metformin is among the first-line treatments for management of the type 2 diabetes mellitus which may have some anti-depressant effect. objective: current investigation was performed to examine the anti-depressant effects of metformin and the involvement of nitric oxide (no) in this way, in an expe...

background: the renin-angiotensin system has an important role in hepatic inflammation and fibrosis. renin-angiotensin system blockade by angiotensinconverting enzyme (ace) inhibitors provides some protective effects against hepatic fibrogenesis. captopril as an ace inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (bdl) rats. object...

Fascioliasis is a health problem in several countries including the Islamic Republic of Iran.  In a review of the medical publications during 1990-2002, only 22 cases of biliary tract obstruction by fasciola hepatica have been reported.  Herein, we are adding a new case of fasciola hepatica causing bile duct obstruction and presenting with intermittent colicky pain, eosinophilia and bile duct d...

The statement concerning biliary cirrhosis which is commonly found in text-books on pathology is to the effect that obstruction of the bile-duct without infection does not lead to cirrhosis of the liver. This is expressed by Mallory, 1 in a recent article on cirrhosis, as follows: "Apparently uncomplicated bile stasis does not result in any sclerotic process around the hepatic veins where the c...

BACKGROUNDS/AIMS When surgeons face difficulties in dissecting the Calot triangle during cholecystectomy due to severe inflammation or fibrosis, the proximal portion of the gallbladder is left in place to avoid injury to the bile duct; this procedure is called partial cholecystectomy (PC), and it is associated with a much higher complication rate after the operation. METHODS We surveyed the c...

objective(s) the liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. some studies reported a gastric acid secretion reduction in cirrhotic subjects, whi...