Background: To develop a simple and accurate method for the determination of Darunavir in human plasma by liquid-liquid extraction with Verapamil as an internal standard using UPLC-MS/MS. Methods: The separation was achieved on Agilent, Zorbax XDB C18 (2.1 x 50 mm ID, 5 μm) column. samples were chromatographed mobile phase consisting acetonitrile 2mM ammonium formate 0.1% formic acid water (70:...

This paper presents data that supports Accelerator Mass Spectrometry (AMS) as a valid bioanalytical tool for tracing long lived radioisotopes in uses as molecular labels or elemental tracers.

Nanofluidic channels are unique bioanalytical tools that can separate, detect, analyze and concentrate biomolecules. Embedding electodes in such systems increases the functionality by allowing for unique flow control, label-free sensing, and concentration enhancement. In this work, we describe the fabrication process of nanofluidic channels with integrated electrodes, as well as the characteriz...

■ ■ Compatibility with SPE eluate for direct injection IN T RODUC T ION Although tricyclic antidepressants (TCAs) are an older class of drug, they remain pharmacologically relevant. For example, inadequate response to other classes of antidepressants in dosed subjects remains common, ensuring the continued viability of TCAs. Furthermore, the fact that they are significantly less expensive than ...