A hypothesis is presented that electronic and vibrational resonant energy states are important in biochemical reactions due to their coupling to hydrogen transfer reactions. The hypothesis is based upon (1) the involvement of hydrogen in most biochemical reactions, (2) the unique abiity of hydrogen to act as an energy trap for resonant energy and (3) demonstrations of the coupling of resonant e...

This work deals with systems whose dynamics are affine in the control input. Such considered to be significantly differentially expressed a canonical form, namely quadratic (pseudo) port-Hamiltonian representation, order explore further some structural properties usable for tracking-error passivity-based design. Different kinds of linear and nonlinear engineering including an open isothermal homoge...

The incidence of tissue and organ damage caused by various diseases is increasing worldwide. Tissue engineering a promising strategy tackling this problem because its potential to regenerate or replace damaged tissues organs. biochemical biophysical cues biomaterials can stimulate induce biological activities such as cell adhesion, proliferation differentiation, ultimately achieve repair regene...

Many protein and mRNA species occur at low molecular counts within cells, and hence are subject to large stochastic fluctuations in copy numbers over time. Development of computationally tractable frameworks for modelling stochastic fluctuations in population counts is essential to understand how noise at the cellular level affects biological function and phenotype. We show that stochastic hybr...

Spring 2013 | Volume 7 Columbia Undergraduate Science Journal 10 Characterizing the Biomechanical and Biochemical Properties of Mouse Uterine Tissue Eli Mondragon*, Kyoko Yoshida, M.S. Kristin Myers, Ph.D Biomedical Engineering Department, Columbia University, New York, NY 10027 Mechanical Engineering Department, Columbia University, New York, NY 10027 Abstract For a successful pregnancy, the u...

Many parameter estimation problems in chemical or biochemical engineering lead to ill-conditioned and nonconvex optimization problems. For bad starting values the use gradient based result in local optimal solutions. To overcome this drawback, a global optimization approach, Simulated Annealing, has been coupled with a gradient-based SQP approach. To improve the accuracy of the parameter estima...

Adv. Mater. 2021, 31, 2100595 DOI: 10.1002/adma.202100595 Following a typesetting error after proofing, the incorrect authors appeared in affiliations 2 and 3 both html pdf versions of published article. Wenjia Zhang Huadan Xue should be marked as affiliated with Department Radiology, State Key Laboratory Complex Severe Rare Diseases, Peking Union Medical College Hospital. Shukun Li Xuehai Yan ...

Although there have been extensive research efforts to create functional tissues and organs, most successes in tissue engineering have been limited to avascular or thin tissues. The major hurdle in development of more complex tissues lies in the formation of vascular networks capable of delivering oxygen and nutrients throughout the engineered constructs. Sufficient neovascularization in scaffo...

The effective reverse engineering of biochemical networks is one of the great challenges of systems biology. The contribution of this paper is two-fold: 1) We introduce a new method for reverse engineering genetic regulatory networks from gene expression data; 2) We demonstrate how nonlinear gene networks can be inferred from steady-state data alone. The reverse engineering method is based on a...