نتایج جستجو برای: biochemical profiling
تعداد نتایج: 215812 فیلتر نتایج به سال:
Female mammals produce milk to feed their newborn offspring before teeth develop and permit the consumption of solid food. Intestinal enterocytes dramatically alter their biochemical signature during the suckling-to-weaning transition. The transcriptional repressor Blimp1 is strongly expressed in immature enterocytes in utero, but these are gradually replaced by Blimp1(-) crypt-derived adult en...
Kras activation and p16 inactivation are required to develop pancreatic ductal adenocarcinoma (PDAC). However, the biochemical mechanisms underlying these double alterations remain unclear. Here we discover that NAD(P)H oxidase 4 (NOX4), an enzyme known to catalyse the oxidation of NAD(P)H, is upregulated when p16 is inactivated by looking at gene expression profiling studies. Activation of NOX...
materials and methods an oligogearray® (an oligonucleotide-based gene expression array platform) containing 126 wnt signaling pathway-related genes was used to compare gene expressions between primary hcc and adjacent non-tumorous liver tissues from 10 patients with hcc. selected differential genes were identified with real-time rt-pcr and immunohistochemistry (ihc). in particular, the protein ...
background and objectives: the present study was conducted to evaluate the presence of biochemical contents and trace elements, and detect phytochemicals in the edible part extracts of asparagus officinalis dc and chlorophytum comosum linn by hptlc. materials and methods: the biochemical contents and trace elements were determined by different biochemical methods, and trace elements’ presence w...
For kinase inhibitors, intracellular target selectivity is fundamental to pharmacological mechanism. Although a number of acellular techniques have been developed to measure kinase binding or enzymatic inhibition, such approaches can fail to accurately predict engagement in cells. Here we report the application of an energy transfer technique that enabled the first broad-spectrum, equilibrium-b...
Defining the molecular effects of compounds with clinically useful properties remains exceedingly challenging if no a priori assumptions can be made as to the biochemical details of the biological effect observed. We set out to identify the molecular target of violacein, a purple-coloured pigment produced by the Amazon River Chromobacterium violaceum, which is used by indigenous Indians in the ...
Free radicals and reactive oxygen species are generated in the body due to various physiological and biochemical processes. They are responsible for various chronic diseases like cancer, diabetes and oxidative damage of DNA and proteins. There is a huge demand of herbal antioxidant compounds in the market. Padaeria foetida,Tribulus terrestris and Oxalis corniculata are used in traditional healt...
The chickpea (Cicer arieitnum L.) is an important food legume crop of the family Fabaceae with high protein levels that widely grown in rainfed areas prone to drought stress. It a self-pollinated cool season true diploid (2n = 16) nature. relatively cheap and source protein. About 90% by use residual moisture soil without depending on irrigation. In present study, two varieties chickpea, namely...
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