BACKGROUND A novel, biodegradable, aliphatic polyurethane scaffold was designed to fulfill an unmet clinical need in the treatment of patients with irreparable partial meniscal lesions. HYPOTHESIS Treatment of irreparable partial meniscal lesions with an acellular polyurethane scaffold supports new tissue ingrowth. STUDY DESIGN Case series; Level of evidence, 4. METHODS Fifty-two patients...

Abstract Zn-based alloys have found increasing interest as orthopedic biodegradable implantable materials, hence it was the aim of this work to investigate microstructure and corrosion behavior Zn–0.5Al– x Mg cast with different additions in simulated body fluid (SBF). The samples were prepared using a simple stir casting method molten poured iron mold. SEM results showed that adding greatly in...

Magnesium has been recently recognized as a biodegradation metal for bone substitute application. In the present work, porous magnesium-zinc scaffolds were prepared by powder metallurgical process and nano hydroxyapatite (HAP) coating on the Mg-3Zn (wt.%) scaffold was prepared by pulse electrodeposition and alkali treatment processes to improve the corrosion resistance of scaffold. The results ...

The first stem cells considered for the reconstruction of bone were bone marrow mesenchymal stem cells (BMSCs). Subsequently, cells with similar marker expression panel and differentiation potential were found in new sources of cells, such as adipose tissue. This source of stem cells has a promising future in tissue-engineering applications, considering the abundance of this tissue in the human...

Limitations in controlling scaffold architecture using traditional fabrication techniques are a problem when constructing engineered tissues/organs. Recently, integration of two pore architectures to generate dual-pore scaffolds with tailored physical properties has attracted wide attention in tissue engineering community. Such scaffolds features primary structured pores which can efficiently e...

Abstract This study investigated the microstructure, compressive properties and in vitro corrosion behavior of biodegradable Mg– x Zn–0.5Mn–0.5Sr (ZMJ) alloy with Zn content 0 to 5 wt% as-cast state. Increasing ZMJ refined grains from 215 95 µm changed secondary particles Mg 17 Sr 2 6 MgZn phases. As increased, yield strength increased 44 67 MPa due grain boundary strengthening. At immersion ph...

We have developed a biodegradable composite scaffold for bone tissue engineering applications with a pore size and interconnecting macroporosity similar to those of human trabecular bone. The scaffold is fabricated by a process of particle leaching and phase inversion from poly(lactideco-glycolide) (PLGA) and two calcium phosphate (CaP) phases both of which are resorbable by osteoclasts; the fi...

Strategies to engineer bone have focused on the use of natural or synthetic degradable materials as scaffolds for cell transplantation or as substrates to guide bone regeneration. The basic requirements of the scaffold material are biocompatibility, degradability, mechanical integrity, and osteoconductivity. A major design problem is satisfying each of these requirements with a single scaffold ...

Tissue engineering techniques using novel scaffolding materials offer potential alternatives for managing tendon disorders. An ideal tendon tissue engineered scaffold should mimic the three-dimensional (3D) structure of the natural extracellular matrix (ECM) of the native tendon. Here, we propose a novel electrospun nanoyarn network that is morphologically and structurally similar to the ECM of...