One of the most applied methods in drug industry for development of new drugs is 3D-QSAR methodology. As p38-mitogen-activated protein kinase (p38-MAPK) plays a crucial role in regulating the production of such proinflammatory cytokines as tumor necrosis factor-α (TNF-α) and interleukin-1, emerging as an attractive target for new anti-inflammatory agents, we used a 3D-QSAR based method of Compa...

Recently, many concerns are paid for dual action drugs such as ACE/NEP dual inhibitors which have two different biological activities. To identify multiple active drugs by supervised learning approach, a multi-label classification technique is required. In the present work, we investigated the classification of antihypertensive drugs including ACE/NEP dual inhibitors using support vector machin...

Background: There are no RA response predictors for our patients. The decision to initiate a first biological depends on multiple factors such as rheumatologist experience, clinical characteristics of the patient and health system. What is clear that best strategy T2T. Objectives: To know persistence DMARD in patients receiving bDMARDS TNF inhibitors vs DMARDs aimed at other targets. Methods: A...

J. Entomol. Sci. 43(1): 86-94 (January 2008) Abstract Addition of 3 DNA-gyrase inhibitors (i.e., novobiocin, nalidixic acid and oxolinic acid) individually to the NI (New and Improved) oligidic diet for plant bugs was investigated to assess their effect on the biological fitness of Lygus hesperus Knight (Heteroptera: Miridae). Biological fitness was measured by the number, biomass, sex ratio, d...