Introduction In the rapidly changing scientific world, contributions of scientists and engineers are leading to major new solutions of significant medical problems. No longer is the treatment of diabetes, osteoporosis, asthma, cardiac problems, cancer, and other diseases based only on conventional pharmaceutical formulations. Biology and medicine are beginning to reduce the problems of disease ...

Microand nanoscale structures of chitosan were fabricated by nanoimprinting lithography and biochemically functionalized for bionanodevice applications. Chitosan solutions were prepared and a nanoimprinting process was developed for it, where chitosan solution is used as a functional resist for nanoimprinting lithography. A low temperature 90 °C and low pressure 5–25 psi nanoimprinting with pol...

Particles of cowpea mosaic virus (CPMV) have enjoyed considerable success as nanoparticles. The development of a system for producing empty virus-like particles (eVLPs) of the virus, which are non-infectious and have the potential to be loaded with heterologous material, has increased the number of possible applications for CPMV-based particles. However, for this potential to be realised, it wa...

Abstract Symmetric proteins are currently of interest as they allow creation larger assemblies and facilitate the incorporation metal ions in complexes. Recently this was demonstrated by biomineralization cadmium‐chloride nanocrystal via Pizza designer protein. However, mechanism behind formation remained unclear. Here, we set out to investigate driving truncation, mutation, circular permutatio...

Bionanotechnology is the combination of biotechnology and nanotechnology for development biosynthetic environmentally friendly nanomaterial synthesis technology. The presented research work adopted a reliable sustainable approach to manufacturing silver nanoparticles from Brachychiton populneus (BP-AgNPs) leaf extract in aqueous medium. populneus-derived were characterized by UV–Vis spectroscop...

Amyloid fibrils are ordered, insoluble protein aggregates that are associated with neurodegenerative conditions such as Alzheimer's disease. The fibrils have a common rod-like core structure, formed from an elongated stack of β-strands, and have a rigidity similar to that of silk (Young's modulus of 0.2-14 GPa). They also exhibit high thermal and chemical stability and can be assembled in vitro...

The fabrication of well-defined one-dimensional (1D) arrays is becoming a challenge for the development of the next generation of advanced nanodevices. Herein, a simple concept is proposed for the in situ synthesis and self-assembly of gold nanoparticles (AuNPs) into 1D arrays via a one-step process. The results demonstrated the formation of nanoparticle chains (NPC) with high aspect ratio base...

Environmentally responsive proteins and peptides are increasingly finding utility in various engineered systems due to their ability to respond to the presentation of external stimuli. A classic example of this behavior is the influenza hemagglutinin (HA) fusion protein. At neutral pH, HA exists in a non-fusogenic state, but upon exposure to low pH, the conformation of the structure changes to ...

Nanoparticles are emerging as a useful tool for a wide variety of biomedical, consumer and instrumental applications that include drug delivery systems, biosensors and environmental sensors. In particular, nanoparticles have been shown to offer greater specificity with enhanced bioavailability and less detrimental side effects as compared to the existing conventional therapies in nanomedicine. ...

The formation of a protective protein container is an essential step in the life-cycle of most viruses. In the case of single-stranded (ss)RNA viruses, this step occurs in parallel with genome packaging in a co-assembly process. Previously, it had been thought that this process can be explained entirely by electrostatics. Inspired by recent single-molecule fluorescence experiments that recapitu...