The pineal hormone melatonin has been shown to have beneficial effects in many aspects of health. Melatonin has been shown to be an important hormone in the regulation of important biological cycles. It has been shown, in human beings, to induce restfulness, and appears to play an important role in reproduction, having an influence on the onset of puberty (Cavallo, 1993; Puig-Domingo, Webb et a...

Biological clock and magnesium status are linked. Central magnesium regulation may be hypothetized. Balanced magnesium status is requested to obtain efficiency of suprachiasmatic nuclei and of pineal gland. Conventional bright light therapy appears as a speedy and efficient antidepressant medication useful for the treatment of various types of depression, and of non migrainous headaches also. A...

Appropriation of signalling pathways facilitates poxvirus replication. Poxviruses, as do most viruses, try to modify the host cell environment to achieve favourable replication conditions. In the present study, we show that the early growth response 1 gene (egr-1) is one of the host cell factors intensely modulated by the orthopoxviruses VV (vaccinia virus) and CPV (cowpox virus). These viruses...

One of the most bizarre acts of medical malpractice took place over a hundred years ago, and happens to be one of the best documented. This is because the two doctors involved – a surgeon and a physician – corresponded at length about it, and the physician’s letters have been preserved. The case has important lessons for doctors, because it contains so many elements that still put patients at r...

Sunlight sustains life on earth. Sunlight is essential for vitamin D synthesis in the skin. The sun’s ultraviolet rays can be hazardous, however, because excessive exposure causes skin cancer and other adverse health effects. Skin cancer is amajor public health problem;more than 2 million new cases are diagnosed in the United States each year. Ultraviolet radiation (UVR) causes the 3 major form...

The main mechanisms of the chronopathological forms of magnesium depletion associate a low Mg intake with various dysregulating biorhythms. The differentiation between forms with hyperfunction and forms with hypofunction of the biological clock is seminal and the main marker is the production of melatonin (MT). The clinical forms of the various patterns of the chronopathological forms of Mg dep...

Sunlight sustains life on earth. Sunlight is essential for vitamin D synthesis in the skin. The sun’s ultraviolet rays can be hazardous, however, because excessive exposure causes skin cancer and other adverse health effects. Skin cancer is amajor public health problem;more than 2 million new cases are diagnosed in the United States each year. Ultraviolet radiation (UVR) causes the 3 major form...

Sunlight sustains life on earth. Sunlight is essential for vitamin D synthesis in the skin. The sun’s ultraviolet rays can be hazardous, however, because excessive exposure causes skin cancer and other adverse health effects. Skin cancer is amajor public health problem;more than 2 million new cases are diagnosed in the United States each year. Ultraviolet radiation (UVR) causes the 3 major form...

Neural and systemic somatotrophic effects of the ultraviolet component of sunlight through the skin-vitamin D endocrine system are considered as alternate or additional to the neuroendocrine effects of the visual component of light through the retino-diencephalic input. The extensive distribution of soltriol nuclear receptor cells, revealed by autoradiography with tritium-labeled 1,25 dihydroxy...

Any attempt to contemplate the next fifty years of cell biology must do so in the context of a past that encompasses roughly three equivalent periods. The first witnessed the discovery that living organisms are composed of cells, that these arise solely from the growth and division of preexisting cells, that an unbroken series of divisions connects us to a primordial cell providing a material b...