Nanopore sequencing, a novel genomics technology, has potential applications for routine biosurveillance, clinical diagnosis, and outbreak investigation of virus infections. Using rapid sequencing of unamplified RNA/cDNA hybrids, we identified Venezuelan equine encephalitis virus and Ebola virus in 3 hours from sample receipt to data acquisition, demonstrating a fieldable technique for RNA viru...

OBJECTIVE To develop a probabilistic model for discovering and quantifying determinants of outbreak detection and to use the model to predict detection performance for new outbreaks. MATERIALS AND METHODS We used an existing software platform to simulate waterborne disease outbreaks of varying duration and magnitude. The simulated data were overlaid on real data from visits to emergency depar...

Methods Antiviral (oseltamivir, zanamivir) and antibacterial (azithromycin) outpatient (OP) prescriptions and OP ESSENCE coded respiratory syndrome, influenza-like-illness (ILI) or influenza-specific ICD-9CM coded visits were analyzed covering the 2010-2011 and 20112012 influenza seasons (July 1, 2010-July 31, 2012) for 152 VA medical centers and 971 outpatient clinics using VA Corporate Data W...