background  in recent years, many researchers haveattempted to cure diabetes by using stem cells technology. stem cells from different sources have capabilityto differentiateinto insulin producing cells (ipcs) by different methods. the obstaclesof these methods aretheirexpensive materials and complexity ofmethodswhichare practicallydisadvantagesfor producing enough transplantableipcs that can c...

background: regulatory t cells (tregs) and myeloid-derived suppressor cells (mdscs) are two main regulatory cells modulating the immune responses in inflammation and cancer. objective: to investigate and compare tregs and mdscs in peptic ulcer and gastric cancer. methods: patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (nud, n=22), peptic ulcer disease...

introduction: umbilical cord blood is a rich source of hematopoietic cells and can be used in the clinical setting for hematopoietic cell transplantation in graft versus host disease (gvhd). a number of different drugs have been used as prophylaxis against gvhd including corticosteroids, cyclosporine a (cy a) and fk506. in this study, the in vitro effects of fk506 on cord blood mononuclear cell...

Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells frequency and suppressive function in the peripheral blood of newly diagnosed T1D patients in compari...

Background: People occasionally undergo medical diagnostic X-ray examinations and expose their red blood cells to radiation. Radiation that is generated from medical diagnostic X-ray machines is widely used in medical diagnoses. One of the important parameters is kilo-voltage (kV) that is applied across the X-ray tube in medical diagnostic X-ray machines. Kilo-voltage influences the radiation d...

introduction: enrichment of intact peripheral blood dendritic cells (dcs) has been done using rosette and immunomagnetic depletion techniques. material and methods: peripheral blood mononuclear cells were separated using ficoll density gradient centrifugation and t lymphocytes were depleted through reaction with aet- treated sheep red blood cells. the remaining cells were depleted from lineage ...