Irish potatoes is rich in carbohydrate, with varied glucose levels. It is also a very good source of apyrase, an enzyme used for platelet storage. The aim of this study was to explore Irish potatoes as an easily available source for apyrase extraction and purification. Apyrase was extracted from 5 Kg of Irish potatoes. Platelets were derived from 5-10 ml of human whole blood and G6PD activity w...

S ENSITIZATION of animals with allogeneic blood platelets induces accelerated rejection of allogeneic skin as well as renal grafts.2 In the latter instance the histologic lesions of the rejected graft were described as primarily vascular. These as well as earlier observations have suggested that an antigenic relationship exists between blood platelets and vascular endothelium. The experiments t...

The infectivity of hamster scrapie strain 263K was measured in platelets isolated from blood pooled from six hamsters with clinical scrapie. The total number of infectious doses present in the blood pool was 220, out of which only 3.5 infectious doses were associated with platelets. A larger proportion of the total infectivity was recovered from the mononuclear leukocyte fraction. This result i...

Abstract Sepsis and autoimmune diseases remain major causes of morbidity mortality. The last decade has seen a new appreciation platelets in host defense, both immunity thrombosis. Platelets are first responders the blood to microbes or non?microbial antigens. role physiologic is counterbalanced by their pathology, for example, microvascular encounter antigens via innate adaptive immun...

Blood dilution after transfusion fluids leads to diminished coagulant activity monitored by rotational thromboelastometry, assessing elastic fibrin clot formation, or by thrombin generation testing. We aimed to determine the contributions of blood cells (platelets, red blood cells) and plasma factors (fibrinogen, prothrombin complex concentrate) to fibrin clot formation under conditions of haem...