نتایج جستجو برای: blood relatives
تعداد نتایج: 708046 فیلتر نتایج به سال:
We have organized the Pancreatic Cancer Genetic Epidemiology (PACGENE) Consortium to identify susceptibility genes in familial pancreatic cancer (FPC). The Consortium comprises seven data collection centers, a statistical genetics core, and a pathology/archival genotyping core. We recruit kindreds containing two or more affected blood relatives ascertained through incident pancreatic adenocarci...
OBJECTIVE Inflammation is known to alter lipid profiles and to induce insulin resistance. This study was planned to test the hypothesis that familial Mediterranean ferver (FMF) patients and their first-degree asymptomatic relatives may have lipid profile changes and/or insulin resistance, similar to other inflammatory diseases. MATERIAL AND METHODS We studied 72 FMF patients, 30 asymptomatic ...
BACKGROUND Mutations in the BRCA1 (MIM 113705) gene are found in many families with multiple cases of breast and ovarian cancer, and women with a BRCA1 mutation are at significantly higher risk of developing breast and ovarian cancer than are the general public. METHODS We obtained blood samples and pedigree information from 3568 unselected cases of early-onset breast cancer and 609 unselecte...
BACKGROUND Coeliac disease (CD), due to its protean clinical manifestation, is still very under diagnosed in adults and delays in diagnosis may take years and even decades. Simple tools to find cases in primary care may help to identify patients for further diagnostic tests. We have evaluated the usefulness of an on site rapid fingertip whole blood point-of-care test (POCT) for such a purpose. ...
OBJECTIVE The link between hyperglycemia and the complications of diabetes is unknown. It is still discussed whether oxidative stress precedes or merely reflects diabetic complications. To search for a familial predisposition to oxidative stress, we investigated indexes of glucose and lipid metabolism, markers of plasma and cell lipid oxidation, a marker of oxidant-induced protein damage, and t...
OBJECTIVE To examine reactivity to anti-citrullinated protein/peptide antibodies (ACPAs) and determine associations between ACPAs and other rheumatoid arthritis (RA)-related autoantibodies and clinically assessed swollen or tender joints in unaffected first-degree relatives of RA patients. METHODS Serum samples were obtained from first-degree relatives without RA according to the 1987 America...
مرگ فرزند بزرگترین و عمیق ترین اندوه در زندگی فرد بوده و وسیعترین واکنشها را در وجود آدمی بر می انگیزد. از دست دادن یک فرزند می تواند باعث ناراحتکننده ترین و طولانی ترین سوگواری گردد. چنین والدینی، فرزند و شیوه زندگی و همچنین امید به زندگی آینده را از دست خواهند داد. والدین اغلب در هنگام مصیبت احساس انزوا می کنند. دوستان، بستگان و همسایگان نمی دانند چه بگویند یا چگونه کمک کنند به همین دلیل از ...
It has been postulated that depressed membrane sodium transport is a necessary step in blood pressure elevation in essential hypertension. Accordingly, leucocyte sodium efflux-rate constants were estimated in 14 normotensive subjects who had one or more first-degree relatives with essential hypertension, and also in 14 matched control subjects with no such family history, before and after takin...
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