BACKGROUND There are limited data about the epidemiology and treatment-related outcomes associated with capreomycin resistance in patients with XDR-TB. Capreomycin achieves high serum concentrations relative to MIC but whether capreomycin has therapeutic benefit despite microbiological resistance remains unclear. METHODS We reviewed the susceptibility profiles and outcomes associated with cap...

A screening-level aquatic probabilistic risk assessment was completed to determine the potential risks of organic pesticides found in surface waters of the C-111 freshwater basin (11 sites at the east boundary of the Everglades National Park) and adjacent estuarine tidal zones (two sites in northeast Florida Bay, one site in south Biscayne Bay) in south Florida. It followed the US Environmental...

Comparison of the amino acid sequence of rat liver NADPH-cytochrome P-450 oxidoreductase with that of flavoproteins of known three-dimensional structure suggested that residues Tyr-140 and Tyr-178 are involved in binding of FMN to the protein. To test this hypothesis, NADPH-cytochrome P-450 oxidoreductase was expressed in Escherichia coli using the expression-secretion vector pIN-III-ompA3, and...

BACKGROUND c-MET has recently been identified as a promising novel target in non-small cell lung cancer (NSCLC). We detected the consistency of c-MET gene amplification in metastatic lymph nodes and tumor tissues of NSCLC patients and discuss the clinical application value of c-MET gene amplification in metastatic lymph nodes. METHODS Real-time fluorescent quantitative PCR was used to test tu...

BACKGROUND This article discusses the value of high-resolution computed tomography (HRCT) in the diagnosis and treatment of pulmonary infections. Lung infection caused by pathogens is an important cause of death. Traditional methods to treat lung infection involved empirical antibiotic therapy. Thin-slice CT scanning is widely used in the clinical setting, and HRCT scan can very clearly show al...

The canonical pathway of regulation of the GCK (germinal centre kinase) III subgroup member, MST3 (mammalian Sterile20-related kinase 3), involves a caspase-mediated cleavage between N-terminal catalytic and C-terminal regulatory domains with possible concurrent autophosphorylation of the activation loop MST3(Thr(178)), induction of serine/threonine protein kinase activity and nuclear localizat...

[This corrects the article on p. 178 in vol. 9, PMID: 26074755.].

Abstract The BL Lac object PKS 0735+178 has shown some complex multiwavelength variation phenomena in previous studies, especially its color behavior. Bluer-when-brighter, redder-when-brighter, and achromatic behavior were all found to be possible long-term trends of 0735+178. In this work, we collected data on 0735+178, also performed a multicolor optical monitoring intraday timescales. Intrad...