The human antimicrobial peptide beta-defensin-2 (hBD2) shows broad antibacterial activity and infrequent bacterial resistance. Here mesoporous bioactive glass (MBG) was loaded with hBD2, forming hBD2-loaded MBG (BD-MBG). osteogenic effects of BD-MBG were investigated in comparison the blank control (BC). result showed that yielded sustained hBD2 release for more than 7 weeks vitro, resulted sig...

Abstract Background N -hexane, with its metabolite 2,5-hexanedine (HD), is an industrial hazardous material. Chronic hexane exposure causes segmental demyelination in the peripheral nerves, and high-dose intoxication may also affect central nervous system. Demyelinating conditions are difficult to treat stem cell therapy using bone marrow mesenchymal cells (BMSCs) a promising novel strategy. Ou...

In many physical systems, the variables that define the performance cannot be measured directly. This may for instance stem from constraints on sensor cost, or from physical limitations in sensor placement. The performance has to be inferred from the measured variables with models, and is therefore inherently determined by model accuracy, see [1] for inferential control in the process industry,...

In order to overcome the limitations of the standard first or-der model of traffic flow (LWR model), various second ordermodels involving relaxation and/or anticipation terms wereintroduced in the literature. These models have the particu-larity to possess an equilibrium which can be unstable if cer-tain so-called subcharacteristic conditions are not satisfied.It can...

BACKGROUND AND OBJECTIVES The receptor activator of NF-kB ligand (RANKL) has a critical role in osteoclast activation. Recently it has been demonstrated that human multiple myeloma (MM) cells do not express RANKL but up-regulate RANKL in bone marrow stromal cells (BMSC). To further investigate the role of RANKL in the pathophysiology of MM we evaluated the expression of its receptor RANK in MM ...

Spinal cord injury (SCI) causes a significant amount of bone loss, which results in osteoporosis (OP). The neuropeptide substance P (SP) and SP receptors may play important roles in the pathogenesis of OP after SCI. To identify the roles of SP in the bone marrow mesenchymal stem cell derived osteoblasts (BMSC-OB) in SCI rats, we investigated the expression of neurokinin-1 receptors (NK1R) in BM...

This retrospective report presents findings on 7 patients with idiopathic dilated cardiomyopathy who underwent transplantation of autologous bone marrow derived mononuclear cells (BMSC) after failed routine conservative treatment, and were on a waiting list for cardiac transplantation. In two out of seven patients, we performed intramyocardial delivery of BMSC twice, 22 and 24 months respective...

In this article, the author reviews recent advancements of basic research on bone marrow stromal cell (BMSC) transplantation for ischemic stroke. The BMSCs are easily isolated from the patients themselves and transplanted into them without any ethical and immunological problem. Animal experiments have shown that BMSC transplantation significantly enhance the recovery of motor and/or cognitive f...

Renal stem cells are still a hot topic, but their location and mechanism of action continue to elude. The therapeutic potential of intrinsic stem cells to the recovery of damaged kidney has been suggested by a number of recent experiments, whereas the role of various other kinds of administered stem cells is still controversial. There are two large questions to address regarding the role of ste...

back ground  subsequent to spinal cord injury many pathological changes may occur that could lead to inappropriate environment for repair. the most important of such changes is the death of neurons. exogenous administration of growth factors that modulate neuronal survival, synaptic plasticity, and neurotransmission has been proposed as a potential therapeutic treatment for sci. among these gro...