The median (range) age and PSA level of the patients was 63 (41–80) years and 4.9 (1.5–67.0) ng/mL, respectively. Of the 100 patients, 34% had normal findings (benign prostatic tissue, BPT), 39% had cancer, 26% had HGPIN and cancer, 22% had HGPIN alone, and 5% had AG. Repeat biopsies were available in nine of the 22 (41%) patients with HGPIN, four of five with AG, and 10 of the 34 (29%) with BP...

Early surgery is vital in the treatment of pancreatic cancer, which is often fatal. However, there is currently no useful noninvasive biomarker to screen for pancreatic cancer. Studies have documented that many salivary molecules can be used to detect systemic diseases. We investigated whether salivary miRNAs are useful biomarkers for detecting resectable pancreatic cancer. Using an Agilent mic...

It has been claimed, perhaps fairly, that psychoanalysis and psychodynamic psychotherapies have failed to promote a culture of systematic evaluation and that the outcomes are difficult to measure and demonstrate. Relative to the number of studies on the effectiveness of cognitive behavioural therapy, few adequate studies are available of psychodynamic therapy outcomes. A growing body of studies...

Abstract Background Hip fractures are a significant cause of morbidity and mortality amongst older adults. The Irish Fracture Database Standard 5 requires that all patients with hip fracture have bone health assessment completed; most commenced on protection therapy (BPT) to reduce future fractures. Communication general practitioners (GPs) regarding long-term BPT is often incomplete challengin...

Dialectical Behavior Therapy, Acceptance and Commitment Therapy, and Functional Analytic Psychotherapy have recently come under fire for “getting ahead of their data” (Corrigan, 2001). The current article presents a descriptive review of some of the actual evidence available. Dialectical Behavior Therapy and Acceptance and Commitment Therapy have a small but growing body of outcome research sup...

Sphingolipid (SL) metabolites have been suggested to be important inflammatory mediators in airway inflammation and asthma. However, little is known about SL metabolites in aspirin-exacerbated respiratory disease (AERD). We aimed to explore the potential AERD biomarkers by conducting lipidomics targeting SL metabolites. The levels of SL metabolites in serum and urine samples from 45 AERD patien...

BACKGROUND Bronchial hyperresponsiveness (BHR), a characteristic feature of asthma, can be assessed through standardized bronchial provocation tests (BPT). Exercise as a BPT is used in diagnosing and monitoring exercise induced bronchoconstriction (EIB). Recently a novel osmotic BPT has been developed, using dry powder mannitol. The aim of this study was to investigate the clinical utility of t...

The latent topic model plays an important role in the unsupervised learning from a corpus, which provides a probabilistic interpretation of the corpus in terms of the latent topic space. An underpinning assumption which most of the topic models are based on is that the documents are assumed to be independent of each other. However, this assumption does not hold true in reality and the relations...

OBJECTIVES Despite the considerable and growing body of research about the clinical effectiveness of long-term psychoanalytic treatment, relatively little attention has been paid to economic evaluations, particularly with reference to the broader range of societal effects. In this cost-utility study, we examined the incremental cost-effectiveness ratio (ICER) of psychoanalysis versus psychoanal...

Introduction:Weight regain may occur with bariatric surgery and it depends on nutritional, psychological and surgery-related factors. The persistence of body shape concern and uneasiness after weight loss is considered a risk factor for weight regain. Weight loss after Bariatric surgery determines change of the cognitive-behavioral component of Body Image, but not the emotional one. The aim of ...