BACKGROUND Arsenic is a ubiquitous toxic element and is known to contaminate drinking water in many countries. Several epidemiological studies have shown that arsenic exposure augments the risk of bone disorders. However, the detailed effect and mechanism of inorganic arsenic on osteoblast differentiation of bone marrow stromal cells and bone loss still remain unclear. OBJECTIVES We investiga...

Bone remodeling is a tightly regulated resorption and formation of bone matrix for physiological processes or to maintain function. involves the synchronized differentiation activity bone-related cell types including matrix-depositing osteoblasts, matrix-resorbing osteoclasts, collagen/extracellular matrix-producing chondrocytes, progenitors these types. T B cells are adaptive immune that can i...

background: mechanotransduction plays a pivotal role in remodeling and repair of skeletal tissues. this mechanism has been widely used in bone tissue engineering especially under in vitro conditions. to date, various stem cells have been used for this purpose. the present study was thefirst to evaluate the effect of mechanical loading on differentiation of human endometrial stemcells (hescs) to...

In this issue, we explore the role of biologics in spinal fusion. The treatment disorders has been revolutionized over last 25 years with introduction to enhance bone density preparation for surgery and promote bony arthrodesis fusion surgery. use these products become even more important era minimally invasive surgery, where graft surface area is at a premium.Use osteobiologics known migration...

Bone marrow stromal cells maintain the adult skeleton by forming osteoblasts throughout life that regenerate bone and repair fractures. We discovered that subsets of these stromal cells, osteoblasts, osteocytes, and hypertrophic chondrocytes secrete a C-type lectin domain protein, Clec11a, which promotes osteogenesis. Clec11a-deficient mice appeared developmentally normal and had normal hematop...

It is well known that bone marrow contains mesenchymal stromal cells (MSCs), which can show osteoblastic differentiation when cultured in osteogenic medium containing ascorbic acid, beta-glycerophosphate and dexamethasone. The differentiation results in the appearance of osteoblasts, together with the formation of bone matrix; thus, in vitro cultured bone (osteoblasts/bone matrix) could be fabr...

The ability of mesenchymal stem cells (MSCs) to differentiate into osteogenic lineages requires management for their future use in treating bone destruction and osteoporosis. Hepcidin is closely associated with bone metabolism, however, it remains to be elucidated whether hepcidin affects osteogenic differentiation in MSCs. The present study demonstrated that hepcidin enhanced osteoblastic diff...

Bone remodeling, a coupled process involving bone resorption and formation, is initiated by mechanical signals and is controlled by local and systemic factors that regulate osteoblast and osteoclast differentiation and function. An excess of resorption over formation leads to the bone loss and increased propensity to fracture that is characteristic of osteoporosis. A newly described inhibitor o...

Parthenolide, a natural product derived from Feverfew, prevents septic shock and inflammation. We aimed to identify the effects of parthenolide on the RANKL (receptor activator of NF-κB ligand)-induced differentiation and bone resorbing activity of osteoclasts. In this study, parthenolide dose-dependently inhibited RANKL-mediated osteoclast differentiation in BMMs, without any evidence of cytot...

Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo. We have previously shown that the Gli2 transcription activator critically mediates Ihh function in osteoblastogenesis. To explore the possibility that activation of Hedgehog (Hh) signaling may enhance bone formation, we generated mice that expressed a constit...