The effect of type 1 diabetes on bone healing and bone formation in standardized craniotomy defects created in BALB/cByJ mice was determined. The hypothesis that advanced glycation end products (AGEs) contribute to diminished bone healing in diabetes was evaluated by assessing for the presence of the receptor for advanced glycation end products (RAGE) by immunohistochemistry in healing cranioto...

the biological interaction between the jaw bones and dental implant is fundamental for the long-term success of dental implant placement. nevertheless, the insufficient bone volume remains a major clinical problem, especially in case of immediate dental implant. using a canine model, the present study proves the regenerative potential of adipose- derived stem cells (adscs) to repair peri-implan...

Other SectionsAbstractINTRODUCTIONBIOLOGY OF BONE FRACTURESANGIOGENESIS IN FRACTURESBONE HEALING PROCESSPHOTOBIOMODULATION THERAPY FOR REGENERATIONCONCLUSIONACKNOWLEDGMENTSAUTHOR CONTRIBUTIONSCONFLICT INTERESTFUNDINGDATA AVAILABILITYReferences

We compared the bone healing capacity of three different demineralized bone matrix (DBM) products applied using different carrier molecules (hyaluronic acid [HA] vs. carboxymethylcellulose [CMC]) or bone compositions (cortical bone vs. cortical bone and cancellous bone) in a rabbit segmental defect model. Overall, 15-mm segmental defects in the left and right radiuses were created in 36 New Zea...

Objective- Bone regeneration is a multifactorial phenomenon which contributed to several factors. It is reported that risedronate is effective for musculoskeletal diseases. The current study was to determine effectiveness of the risedronate-loaded nano capsules for calvaria healing in rabbit.Design- Experimental study.Procedures- 15 white adult male New Zealand rabbits were used. Fo...

A state of chronic immobility resulting from extended spaceflight, bed rest or paralysis can present severe secondary complications for individuals confronted with long bone cortical fractures that fail to heal. These secondary complications can generally lead to a decreased quality of life and function for these individuals, and may potentially lead to a life-threatening situation. One potenti...

BACKGROUND Simple bone cysts are common benign lesions in growing children that predispose them to fracture and are sometimes painful. The purpose of this trial was to compare rates of healing of simple bone cysts treated with intralesional injections of bone marrow with rates of healing of those treated with methylprednisolone acetate. METHODS Of ninety patients randomly allocated to treatme...

Previous studies have shown substantial effect thermal damage can have on new bone formation following osteotomy. In this study we evaluated the extent of thermal damage which occurs in four different methods of osteotomy and the effects it can have on bone healing. We further wanted to test whether a special osteotomy plate we constructed can lead to diminished heat generation during osteotomy...

Skeletal regeneration and bone fracture repair involves complex cellular and molecular events that result in new bone formation. Many of the critical steps during bone healing are dependent on the local mechanical environment in the healing tissue. Computational models are used together with mechano-regulation algorithms to predict the influence of mechanical stimuli on the tissue differentiati...

This thesis relates to some new aspects on the regulation of bone healing. In the last few years, Wnt signaling has been shown to play a central role in bone biology. As well as being involved in bone maintenance and repair, Wnt signaling has been presented as one of the ke y pathways through which bone responds to mechanical load. Two secreted extracellular inhibitors of Wnt signaling, scleros...