abstract vascular injury presents a great challenge to the emergency resident because these injuries require urgent intervention to prevent loss of life or limb. sometimes serious vascular injury presents with only subtle or occult signs or symptoms. the patient may present weeks or months after initial injury with symptoms of vascular insufficiency, embolization, pseudoaneurysm, arteriovenous ...

BACKGROUND Pediatric supracondylar fracture and forearm bone fracture is common in isolation but combined supracondylar fracture with ipsilateral forearm bone fracture, known as floating elbow is not common injury. The incidence of this association varies between 3% and 13%. Since the injury is rare and only limited literatures are available, choosing best management options for floating elbow ...

Alendronate, a nitrogen-containing bisphosphonate, is well established as a treatment for osteoporosis through regulation of osteoclast activity. Previously, the pharmacological effects of bisphosphonates on cells outside the bone environment have been considered irrelevant because bisphosphonates target bone. Here we show that administration of alendronate impairs muscle regeneration in mice a...

The bone marrow is a complex environment that houses haematopoietic and mesenchymal cell populations and regulates bone turnover throughout life. The high proliferative capacity of these cell populations however, makes them susceptible to damage and injury, altering the steady-state of the bone marrow environment. Following cancer chemotherapy, irradiation and long-term glucocorticoid use, redu...

Background: The fracture of the mandible is the second most common facial bone injury.  When this injury occurs, it could be serious with complications that may even result in death. Objective: To evaluate the current trends in mandibular fracture (MF) in southern Iran. Methods: In a cross-sectional study, several parameters including age, sex, cause of fracture, anatomical site of fracture, pr...

thisis a case report of a 24-year-old man who presented with increased pain and firm swelling of the right foot after a minor twisting injury. radiography, computed tomography (ct) and magnetic resonance imaging (mri) findings showed ancillary information that was helpful for surgical treatment. the final diagnosis was confirmed aschondroblastoma of the navicular bone based on the pathology rep...

OBJECTIVES Toll-like receptors (TLR) 2 are expressed in cardiac and inflammatory cells, and regulate leukocyte function. Because leukocyte adhesion is a critical event in endothelial injury induced by ischemia/reperfusion (I/R), we assessed whether TLR2 were involved in I/R-induced coronary endothelial injury. METHODS AND RESULTS Ischemia-reperfusion markedly decreased NO-mediated coronary re...

Concomitant traumatic brain injury (TBI) and long bone fracture are commonly observed in multitrauma and polytrauma. Despite clinical observations of enhanced bone healing in patients with TBI, the relationship between TBI and fracture healing remains poorly understood, with clinical data limited by the presence of several confounding variables. Here we developed a novel trauma model featuring ...

Eleven subjects participated in a prospective placebo-controlled trial to address the efficacy of pamidronate in reducing bone loss in persons with acute spinal cord injury (SCI). We administered pamidronate (treatment) or normal saline (placebo) intravenously at baseline (22 to 65 days after injury) and sequentially over 12 months, with follow-up at 18 and 24 months. Regional bone mineral dens...

CONTEXT Osseous injury to the glenoid is increasingly being recognized as one of the most important aspects in the successful management of recurrent shoulder instability. Proper early recognition of glenoid bone injury in the setting of recurrent instability will lead to successful nonoperative and operative decision making, particularly in the athletic patient. EVIDENCE ACQUISITION We condu...