Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) usually occurs in a setting of systemic infection or graft-versus-host reaction during the first weeks following transplant. We report a case of fatal TTP that developed eight months after allogeneic bone marrow transplantation (BMT) without any evident association with other transplantation-related complications. Condition...

Outcomes after peripheral blood stem cell transplantation (PBSCT) for chronic phase chronic myeloid leukemia (n = 37) were compared with outcomes after bone marrow transplantation (BMT) (n = 54) in the HLA-compatible unrelated donor setting. Median follow-up was 17 months after PBSCT and 29 months after BMT. Both neutrophil and platelet recovery were faster after PBSCT (P <.05). PBSCT was assoc...

A patient with acute leukemia and her family including four HLA-identical siblings were analyzed to select a donor who was not only HLA- but also minor histocompatibility (mH) antigen compatible for allogeneic bone marrow transplantation (BMT). The HLA-A2 restricted mH antigen-specific HA-1, -2, -4, and -5 cytotoxic T-lymphocyte (CTL) clones were used to type the family members for expression o...

We have recently shown that the use of allogeneic granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood hematopoietic stem cell transplantation (PBHSCT), as compared with bone marrow transplantation (BMT), is associated with increased titers of antibodies (Abs) directed against red blood cell ABO antigens. To further evaluate the influence of a G-CSF-mobilized PBHSCT graft on...

Bone marrow transplantation (BMT) has become an increasingly common treatment option for those patients who have a disease that affects the bone marrow (BM) directly or indirectly. Because of the level of immunosuppression achieved in BMT, any problems the pediatric patient presents in the oral cavity can become life-threatening and increase the length of hospital stay, the patient's discomfort...

Chronic myelomonocytic leukemia (CMML) is a rare hematoHowever, they did display some characteristic hematologic poietic malignancy of childhood. To define the clinical and features. Of 110 children, 38 received an allogeneic bone hematologic characteristics of the disease, we performed a marrow transplant (BMT). The probability of survival at 10 retrospective analysis of 110 children given the...

Overview. The Computerized Decision Support System project (CDSS) develops and evaluates a web-based computer system for bone marrow transplant (BMT) long-term follow-up (LTFU) at the Fred Hutchinson Cancer Research Center (FHCRC). The CDSS system aims at providing an information and knowledge resource capable of assisting the clinical work of users having very diverse expertise levels in BMT p...

Bone marrow transplantation (BMT) is used to treat hematological disorders, autoimmune diseases (ADs) and lymphoid cancers. Intra bone marrow-BMT (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hematopoietic recovery and the complete restoration of T cell functions. IBM-BMT not only replaces hematopoietic stem cells (HSCs) but also mesenchymal stromal cel...

The area of hematopoietic stem cell transplantation (HSCT) has grown immensely since its beginnings. The roots of bone marrow transplantation (BMT) can be traced back to 1949 when Leon Jacobson and his colleagues performed mouse experiments and discovered that mice could recover from lethal irradiation if their spleens were shielded (Appelbaum, 1996). Lorenz, Uphoff, Reid, and Shelton demonstra...

Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...