نتایج جستجو برای: bone substitute
تعداد نتایج: 323812 فیلتر نتایج به سال:
Although bone grafting has a well-recognised role in orthopaedic surgery for the treatment of nonunion, bridging diaphyseal defects and filling metaphyseal defects, it is associated with postoperative pain and morbidity. When extensive grafting is required, as in spinal arthrodesis and the management of large bony defects, inadequate amounts of autologous bone may not be available. Allograft bo...
NELL-1 (NEL-like Protein 1) is an osteoinductive protein with increasing usage as a bone graft substitute in preclinical animal models. NELL-1 was first identified to have bone-forming properties by its overexpression in fusing cranial sutures. Since this time, addition of recombinant NELL-1 has been used to successfully induce bone formation in the calvarial, axial and appendicular skeleton. W...
PURPOSE Pluripotent cells residing in the periosteum, a bi-layered membrane enveloping all bones, exhibit a remarkable regenerative capacity to fill in critical sized defects of the ovine femur within two weeks of treatment. Harnessing the regenerative power of the periosteum appears to be limited only by the amount of healthy periosteum available. Here we use a substitute periosteum, a deliver...
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