Objectives. To assess the immunogenicity of intradermal (ID) booster doses of Purified Chick Embryo Cell rabies vaccine (PCECV, Rabipur) administered to Thai schoolchildren one, three and five years after a primary ID pre-exposure (PrEP) vaccination series. Methods. In this follow-up study of a randomized, open-label, phase II clinical trial, two simulated post-exposure booster doses of PCECV w...

The efficacy of brief treatments for media-recruited pathological gamblers was tested in a randomized clinical trial design (N = 314). Two self-directed motivational interventions were compared with a 6-week waiting list control and a workbook only control. Brief motivational treatment involved a telephone motivational interview and a mailed self-help workbook. Brief motivational booster treatm...

OBJECTIVE To assess persistence of immunity to hepatitis B (HBV) in primary school children vaccinated following perinatal exposure. DESIGN Serological survey. SETTING Five UK sites (Berkshire East, Birmingham, Buckinghamshire, Milton Keynes and Oxfordshire). PARTICIPANTS Children from 3 years 4 months to 10 years of age (mean age 6.2 years), vaccinated against HBV from birth following pe...

This paper describes a novel approach to increase the performance of web sites by changing the network traffic between the client and the web servers. This is achieved by introducing a web booster architecture, which instantaneously decreases the processing cost on a web server for requests to both static and dynamic web resources. It consists of a booster appliance, which pre-processes client ...

BACKGROUND We conducted a 5-year follow-up study on the persistence of pertussis-specific antibody and cell-mediated immunity after booster immunization of adolescents aged 11-13 years with a tricomponent acellular pertussis vaccine (Boostrix; trials diphtheria-tetanus-acellular pertussis [Tdap]-004/030). METHODS Cellular and humoral immunity to pertussis toxin (PT), filamentous hemagglutinin...

BACKGROUND A significant waning of enterovirus 71 (EV71) antibody titer after priming immunization with an inactivated EV71 vaccine implied the potential need for a booster dose. METHODS In this randomized, double-blind, placebo-controlled clinical trial, we recruited participants who had received at least 1 dose of priming EV71 vaccine in an early phase 2 clinical trial that was conducted in...

A flight test article, called a glove, is required for a Mach-8 boundary-layer experiment to be conducted on a flight mission of the air-launched Pegasus® space booster. The glove is required to provide a smooth, threedimensional, structurally stable, aerodynamic surface and includes instrumentation to determine when and where boundary-layer transition occurs during the hypersonic flight trajec...

OBJECTIVES This article presents the response of a child-size postmortem human subject using a booster seat in a series of three frontal impact sled tests. METHODS A 54-year-old female cadaver was seated in a booster seat in the rear seat of a buck representing a mid-sized American sedan. Two different restraint systems (conventional belt and pretensioning, force-limiting belt) were used to r...

Pertussis is the only vaccine-preventable disease on the rise in the United States, with increasing incidence in adolescents and adults related to waning immunity. Although often considered a relatively mild infection in these populations, pertussis can be a serious, potentially deadly illness, particularly in children <12 months old. Infected adolescents and adults serve as a reservoir for dis...

BACKGROUND Whether hepatitis B (HB) vaccine-conferred immunity persists into adulthood is unknown. We aimed to investigate long-term HB immunity in adolescents. METHODS In 2004-2005, 6156 high school students (15-21 years old) who had been vaccinated with plasma-derived HB vaccine as infants were recruited for HB seromarker screening. The immune response to an HB vaccine booster was evaluated...