Toxic epidermal necrolysis (TEN) is a severe drug induced type IV hypersensitivity syndrome that can be caused by anticonvulsant drugs, especially the aromatic anticonvulsants such as phenytoin. Most patients with brain metastasis receive whole brain radiotherapy along with anti-edema measures and anticonvulsants either as prophylactic or for symptom control; phenytoin being the most commonly u...

We examined recurrence after gross total resection (GTR) or subtotal (STR) at St. Michael’s Hospital, Toronto, of 181 cases atypical meningioma (WHO grade II). In the entire group, Kaplan-Meier survival curves showed that combined necrosis and brain invasion was feature associated with worst outcome, followed in order by necrosis, histological variants (clear cell, rhabdoid, chordoid), high mit...

Abstract AIMS Imaging of tumour habitats is a novel technique to assess regional treatment response by defining ‘habitats’, which are regions with shared imaging characteristics. Here, we describe pipeline characterise in glioblastoma using bioinformatics and machine learning. We apply this patients the Preoperative Brain Irradiation Glioblastoma (POBIG) trial that received preoperative radioth...

Abstract Background Despite current advances in systemic therapy for brain metastases, neurosurgery remains the preferred method of choice patients with limited metastases. Postoperative radiotherapy indicated to reduce risk local recurrence is recommended all after surgery. The aim this retrospective study describe clinical characteristics and survival outcomes consecutive cohorts treated by c...

BACKGROUND Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death in Australia. Radiotherapy plays an important role in the curative and palliative settings. OBJECTIVE This article reviews recent technological advances that have expanded the radiotherapy treatment options available, and presents standard and emerging approaches to NSCLC. DISCUSSION General practitione...

This study was designed to estimate radiation-induced secondary cancer risks from high-dose-rate (HDR) brachytherapy and external radiotherapy for patients with cervical cancer based on measurements of doses absorbed by various organs. Organ doses from HDR brachytherapy and external radiotherapy were measured using glass rod dosimeters. Doses to out-of-field organs were measured at various loca...

Nine out of 14 patients treated with intraventricular methotrexate (MTX) for meningeal carcinomatosis from breast carcinoma and surviving more than 4 months developed disseminated necrotising leukoencephalopathy (DNL). All four patients who had received both intraventricular MTX and whole brain radiotherapy developed DNL. Five of the six patients who experienced an acute febrile reaction with m...