The elasticity of biological tissues is one the physical characteristics and has attracted attention as a clinical diagnostic parameter. can be determined on microscopic scale with speed sound (SoS) measurements using acoustic microscopy. In SoS measurements, thin-sliced section attached to glass slide in same manner light specimen. There are two main methods for preparing thin sections: paraff...

Abstract Background Synthetic cannabinoids are one of the largest groups new psychoactive substances that invaded Egypt’s drug abuse market over past few years. Aim Randomized controlled trial study to demonstrate effects acute and chronic toxicity by synthetic cannabinoid (Strox) on brain, liver, heart, testes in adult male albino rats through histopathological examination light microscope imm...

SUMMARY In this study, we compared 8-T gradient-echo MR images of the microvasculature in the live human brain with images of the unembalmed and embalmed postmortem brain. Small vessels were well visualized in the live brain and even better seen in the unembalmed postmortem brain, but they could not be visualized in the embalmed postmortem brain. These findings are important for direct comparis...

Extracellular accumulation of amyloid-beta (Aβ) plaques is one the major pathological hallmarks Alzheimer's disease (AD), and target only FDA-approved disease-modifying treatment for AD. Accordingly, use transgenic mouse models that overexpress amyloid precursor protein thereby accumulate cerebral Aβ are widely used to model human AD in mice. Therefore, immunoassays, including enzyme-linked imm...

Imaging of β-amyloid (Aβ) plaques in the brain may facilitate the diagnosis of cerebral β-amyloidosis, risk prediction of Alzheimer's disease (AD), and effectiveness of anti-amyloid therapies. The purpose of this study was to evaluate novel (123)I-labeled pyridyl benzofuran derivatives as SPECT probes for Aβ imaging. The formation of a pyridyl benzofuran backbone was accomplished by Suzuki coup...

Objective(s): Amyloid β plaques, in Alzheimer’s disease, are deposits in different areas of the brain such as prefrontal cortex, molecular layer of the cerebellum, and the hippocampal formation. Amyloid β aggregates lead to the release of cytochrome c and finally neuronal cell death in brain tissue. hCG has critical roles in brain development, neuron differentiation, and function. Therefore, we...

Miconazole is an imidazole antifungal agent, commonly applied topically to the skin or mucous membranes. The aim of this study was to examine the alternative method for gaining mechanism or the bimolecular changes caused by the possible teratogenic effects of Miconazole on mice fetus brain tissue using FTIR-Microspectroscopy. The mice were injected with Miconazole (60 mg/Kg) on gestation day 9....