In microbial infections, the interaction between microorganisms and phagocytic cells is a crucial determinant in the outcome of the disease process. We used flow cytometry to study the in vitro interactions between Vibrio tapetis, the bacterium responsible for Brown Ring Disease (BRD) in the Manila clam Ruditapes philippinarum, and haemocytes from three bivalve species: the Manila clam (suscept...

Dairy heifer calves experience high levels of contagious disease during their preweaning period, which may result in poor welfare, reduced performance or mortality. We determined risk factors for a cohort study 492 heifers recruited from 11 commercial UK dairy farms. Every animal received weekly examination by veterinarian birth to nine weeks using the Wisconsin scoring system. Multivariable mo...

In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. We show that MLL-AF9 cells critically depend on FLT3-ligand induced pathways as well as on BRD3/4 for their survival. We evaluated the in vitro and in vivo efficacy of the BRD3/4 inhibitor I-BET151 in various human MLL-AF9 (primary) models and patient samples and analyzed the transcriptome changes...

Abstract Bovine respiratory disease (BRD) affects millions of cattle in the US annually. This study sought to identify commensal pathogens animals without clinical signs that were predictive BRD using Wisconsin Health Scoring (WHS) system. Cases healthy later diagnosed with (WHS ≥ 5.0), positive controls (PC) at time initial sampling and negative (NC) those remained throughout ≤ 4.0). Beef feed...

Bovine respiratory disease (BRD) is an economically important disease of cattle and continues to be an intensely studied topic. However, literature summarizing the time between pathogen exposure and clinical signs, shedding, and seroconversion is minimal. A structured literature review of the published literature was performed to determine cattle responses (time from pathogen exposure to clinic...

The purpose of this study was to examine the predictive reliability of incoming grade point average (GPA), incoming math/science GPA, and Scholastic Aptitude Test (SAT) scores in predicting success in dental hygiene education. Success in dental hygiene education was defined in terms of Dental Hygiene National Board score (N-BRD) and dental hygiene GPA at graduation (DH-GPA). Academic transcript...

The severity of bovine respiratory infections has been linked to a variety of factors, including environmental and nutritional changes, transportation, and social reorganization of weaned calves. Fatal respiratory infections, however, usually occur when a primary viral infection compromises host defences and enhances the severity of a secondary bacterial infection. This viral-bacterial synergy ...