72 Background: The TARGIT-A trial allowed administration of IORT both pre- and post-pathology. The advantage of post-pathology is the ability to determine eligibility based on margins, pathologic tumor size and nodal status, prior to delivering radiation. However, it is unclear whether having more than one operation before IORT is associated with worse skin toxicity. In this study, we aimed to ...

AIMS Intraoperative radiotherapy (IORT) for locally advanced rectal cancer as an integral part of multimodal treatment, may lead to reduced local recurrence but it is not routinely used. The aim of this paper is to describe our experience with IORT in the treatment of patients with locally advanced adenocarcinoma of the lower third of the rectum. MATERIAL AND METHODS Laparoscopic abdominoperi...

background: we studied the patterns of premenopausal and postmenopausal breast cancer incidence and its established risk factors in iran in 2010. in addition, we estimated the 5-year prevalence of breast cancer in the country. methods: we performed an internet and library literature review. we used national cancer registry data, demographic health surveys, national censuses and world bank data ...

breast cancer is the most common cancer occurring among women. the mortality rate of breast cancer can be reduced by regular breast cancer screening program. this study was carried out to identify the knowledge and practice of women about breast cancer screening in zahedan, southeast of iran. in this cross- sectional study, 384 women were selected as an improbability sample of women referring t...

background: breast cancer is the most common malignancy in women. breast cancer type 1 susceptibility gene (brca1) is a tumor suppressor gene, involved in dna damage repair and in 81% of the breast-ovarian cancer families were due to brca1. in some clinically investigated genes, the intragenic marker polymorphism is important and the screening of such mutations is faster by using short tandem r...

background: breast cancer incidence has increased rapidly inkuwait, but there haven’t been any studies investigating the recognized risk factors of breast cancer inkuwait. the aim of the study was to investigate breast cancer risk factors among women inkuwait.   methods: a case-control study was conducted in kuwait from may 2003 to march 2004 using a questionnaire including socio-demographic da...

Purpose. Radiation of extremity lesions, a key component of limb-sparing therapy, presents particular challenges, with significant risks of toxicities. We sought to explore the efficacy of intraoperative radiation therapy (IORT) in the treatment of soft tissue sarcomas of the extremities. Patients. Between 1995 and 2001, 17 patients received IORT for soft tissue sarcomas of the extremities. Ind...

Radiotherapy (RT) following breast-conserving therapy has been demonstrated to reduce the risk of breast cancer local recurrence and death (1). The adverse normal tissue effects of radiation have been reduced, but not eliminated, with modern treatment planning techniques. Since the introduction of breast-conserving therapy in the 1980s, analyses of long-term results of randomized trials have id...