Background. Bone and joint infection due to bacteria producing Extended Broad Spectrum Beta lactamase (ESBL) are rare but rising nowadays. Data on this disease are scarce and outcome is not well known. We present a cohort of 43 cases. Methods. Multicentric retrospective cohort of consecutive cases of bone and joint infection due to ESBL producing microorganism identified from the charts of the ...

BACKGROUND AND PURPOSE Infections due to extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae (ESBL-EC and ESBL-KP) have become an important clinical problem. Local knowledge of antimicrobial susceptibilities of these organisms is important for implementation of effective hospital anti-infective policies. METHODS We analyzed the activities of various an...

Antibiotic resistance is a cause for deep concern in the clinical setting. Challenging plans of action to address antimicrobial resistance (AMR) have recently been proposed (1). Among the many mechanisms of antibiotic resistance, extended-spectrum β-lactamases (ESBLs) are enzymes that have the ability to hydrolyze a broader spectrum of βlactam antibiotics and cause resistance to oxyiminocephalo...

Activity of simulated cefditoren urinary concentrations was determined against seven Escherichia coli isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV/TEM-116 (ESBL) but never against SHV/TEM-1 (ESBL). Extension of bactericidal ...

Extended-spectrum beta-lactamases (ESBLs), e.g., ESBLs of the TEM or SHV type, compromise the efficacies of expanded-spectrum cephalosporins. An SHV non-ESBL that hydrolyzes only narrow-spectrum cephalosporins can be converted into an SHV ESBL through substitutions at three amino acid positions, 179, 238, or 238--240. In order to improve detection of SHV ESBLs, a novel method, based on real-tim...

OBJECTIVE To determine the prevalence of extended spectrum beta-lactamase (ESBL) among multidrug resistant isolates of enterobacteriaceae and non-fermenting gram-negative bacilli. METHODS This study was carried out at the Almana General Hospital, Eastern Province, Kingdom of Saudi Arabia, during the period March 2002 through to June 2003. Multidrug resistant gram-negative isolates from patien...

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae have been isolated from humans and animals across the world. However, data on prevalence of ESBL-producing Enterobacteriaceae from rural water reservoirs is limited. This study aimed to isolate and characterize ESBL-producing Enterobacteriaceae in rural water reservoirs in Guantao, China. ESBL-producing Enterobacteriaceae were...

Background The extended spectrum ß-lactamases (ESBL) are enzymes that produce resistance to ß-lactam antibiotics, including penicillins, wide spectrum cephalosporins and aztreonam, by cleavage of ß-lactam ring (BUSH & JACOBY, 2010). Since ESBL-producing bacteria are frequently associated with nosocomial infections, treatment options are becoming increasingly limited (RAWAT & NAIR, 2010). In thi...

Extended spectrum beta lactamases (ESBLs) that mediate resistance to 3rd generation cephalosporins are now observed worldwide in all species of Enterobacteriaceae especially Klebsiella pneumoniae and Escherichia coli. ESBL producing organisms are responsible for nosocomial infections and may result in hospital outbreaks. Present study is a descriptive study. It was planned to determine the freq...