نتایج جستجو برای: bromodeoxyuridine

تعداد نتایج: 5050  

Journal: :Nucleic acids research 1979
L B Taichman

Two procedures are described for the fractionation of chromatin containing unsubstituted (LL) DNA and DNA unifilarly substituted with bromodeoxyuridine (HL). The two procedures rely upon the sensitivity of bromodeoxyuridine-containing DNA to UV light to induce either strand breakage or protein crosslinking. When a mixture of LL and HL chromatin is irradiated with UV light, the HL DNA fragments ...

Journal: :Cancer research 1980
Y Gazitt C Friend

O-Ornithine decarboxylase (ODC) activity in cultures of Friend erythroleukemia cells induced to differentiate with various compounds was examined. Based on ability to stimulate ODC activity, the inducers tested could be divided into two categories. Inducers of the first class, among which were dimethyl sulfoxide and hexamethylene bisacetamide, stimulated ODC activity and were inhibited by dexam...

Journal: :Developmental biology 2000
P A Newmark A Sánchez Alvarado

The singular regenerative abilities of planarians require a population of stem cells known as neoblasts. In response to wounding, or during the course of cell turnover, neoblasts are signaled to divide and/or differentiate, thereby replacing lost cell types. The study of these pluripotent stem cells and their role in planarian regeneration has been severely hampered by the reported inability of...

Journal: :Applied and environmental microbiology 2006
Sarah P Walters Katharine G Field

Extraintestinal growth of fecal bacteria can impair accurate assessment of watershed health. Anaerobic fecal bacteria belonging to the order Bacteroidales are attractive candidates for fecal source tracking because they have host-specific distributions and do not grow well in the presence of high oxygen concentrations. Growth of general and human-specific fecal Bacteroidales marker organisms in...

Journal: :The Journal of clinical investigation 1983
G Morstyn S M Hsu T Kinsella H Gratzner A Russo J B Mitchell

Using a monoclonal antibody to bromodeoxyuridine (BUdR) and immunohistochemistry, we measured the incorporation of this thymidine analogue into the DNA of human normal and malignant cells exposed in vivo. BUdR given as a constant intravenous infusion for 12 or 24 h daily for up to 13 d resulted in a steady-state plasma level of 10(-6) M during the infusion. We demonstrated extensive incorporati...

Journal: :Cancer research 1999
A Doiron D T Yapp M Olivares J X Zhu S Lehnert

We have previously reported that the use of the polymer bis(p-carboxyphenoxy)propane-sebacic acid (20:80) for intratumoral delivery of cis-platinum in a mouse tumor model (RIF-1) potentiated the effects of acute and fractionated radiation. This mode of drug delivery seems particularly applicable to the administration of radiosensitizing drugs because an optimum concentration of radiosensitizer ...

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