BACKGROUND It has been established that patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have co-existing asthma. OBJECTIVE We aimed to test two hypotheses: (i) upper and lower airway inflammation in CRSwNP is uniform in agreement with the united airways concept; and (ii) bronchial inflammation exists in all CRSwNP patients irrespective of clinical asthma status. METHOD...

BACKGROUND The risk of nosocomial infection is increased in critically ill patients by stress hyperglycaemia. Glucose is not normally detectable in airway secretions but appears as blood glucose levels exceed 6.7-9.7 mmol/l. We hypothesise that the presence of glucose in airway secretions in these patients predisposes to respiratory infection. METHODS An association between glucose in bronchi...

Background: The risk of nosocomial infection is increased in critically ill patients by stress hyperglycaemia. Glucose is not normally detectable in airway secretions but appears as blood glucose levels exceed 6.7– 9.7 mmol/l. We hypothesise that the presence of glucose in airway secretions in these patients predisposes to respiratory infection. Methods: An association between glucose in bronch...

Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent chronic diseases in the general population. Both are characterized by similar mechanisms: airway inflammation, airway obstruction, and airway hyperresponsiveness. However, the distinction between the two obstructive diseases is not always clear. Multiple epidemiological studies demonstrate that in elderly people with o...

Obtaining reliable CFD predictions of the bronchial flow that reflects the actual flow within a living lung requires the development of a deforming airways model, and the imposition of physiological subject-specific boundary conditions. This thesis addresses these two issues by the development of dynamic CFD models of the bronchial airways using a dynamic CT data set covering the breathing cycl...

Bronchial Asthma is a major non-communicable disease affecting both children and adults, nearly 262 million people in India suffer from asthma (WHO). It chronic disorder that affects the airways characterized by bronchial hyper-reactivity reversible airway obstruction. could be correlated as Tamak shwasa Ayurveda considered Pranvaha srotho vikara. The Pathya Aahar Vihara, having Vata Kapha alle...

BACKGROUND Despite a long-standing recognition, the bronchial hyperresponsiveness (BHR) of airway smooth muscle, in asthmatic and non-asthmatic subjects is still under investigation. OBJECTIVE In order to better understand the mechanism regulating the airway function, some results obtained with cellular physiology techniques are compared, for some non-asthmatic without BHR subjects and other ...

introduction foreign body aspiration is common especially in children. the absence of history of choking does not rule out the diagnosis. diagnosis required high index of suspicion. case presentation undiagnosed foreign body aspiration mostly occurs in bronchial airway rather than larynx and can cause severe complications. in this article, we report a silent laryngeal foreign body aspiration to...

BACKGROUND The interrelationship between human airway epithelium and complement proteins may affect airway defence, airway function, and airway epithelial integrity. A study was undertaken to determine (1) whether unstimulated human bronchial epithelium generates complement proteins and expresses cell membrane complement inhibitory proteins (CIP) and (2) whether stimulation by proinflammatory c...

To study the physiopathology and significance of asymptomatic airway hyperresponsiveness (AHR), the clinical and bronchial immunohistological parameters were evaluated in subjects with asymptomatic and symptomatic AHR. Asymptomatic subjects with AHR (eight females/two males, no respiratory symptoms, provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one ...