BACKGROUND Patients with allergic rhinitis and allergic asthma demonstrate comparable local and systemic eosinophil inflammation, and yet they present with different clinical pictures. Less is even known about the contribution of neutrophil inflammation in allergic diseases. The aim of the study was to examine the propensity and selectivity of granule release from primed systemic eosinophils an...

Wheezing in early childhood covers a wide spectrum of morbidity. Since little is known about the factors determining either the pattern or the severity of this range of symptoms, 51 children, admitted to hospital with acute wheeze in the first 2 yrs of life, were monitored prospectively between the ages of 4.5-5.5 yrs. Our hypothesis was that the predictors of severe episodes and of interval sy...

PURPOSE To evaluate clinical relevance of high-resolution computed tomographic (CT) findings in patients with bronchiectasis by using a quantitative high-resolution CT protocol to assess extent of bronchiectasis, severity of bronchial wall thickening, and presence of small-airway abnormalities and mosaic pattern. MATERIALS AND METHODS Sixty Chinese patients with steady-state bronchiectasis un...

The present investigation was carried out to determine the efficacy and safety of Lepidium sativum (L. sativum) (Garden Cress, Fam: Cruciferae) in patients of bronchial asthma. L. sativum seed powder was given at a dose of 1 gm thrice a day orally to 30 patients of either sex in the range of 15-80 years with mild to moderate bronchial asthma without any concurrent medication. The respiratory fu...

The lungs of rat fetuses at various stages of gestation and lungs of infant rats were examined histochemically for acetylcholinesterase (AChE) and norepinephrine (NE). No AChE is present in the fetal lungs until 15 days of gestation. At this stage a number of large round cells appear which stain heavily for AChE. These cells disappear by the 18th day of development and at 18 days no AChE-positi...

Background: Bronchial asthma is a widespread chronic airway inflammatory disease, and it characterized by paroxysmal or continual respiratory manifestations airflow limitations. Accordingly, coronavirus disease 2019 (COVID-19) impact on quality of life including daily living activities come into views to be highly misjudged, especially in patients who have not been admitted the hospital. Aim: T...

The F508del-CFTR mutation, responsible for Cystic Fibrosis (CF), leads to the retention of the protein in the endoplasmic reticulum (ER). The mistrafficking of this mutant form can be corrected by pharmacological chaperones, but these molecules showed limitations in clinical trials. We therefore hypothesized that important factors in CF patients may have not been considered in the in vitro assa...