symptoms recovered within few days. The transbronchial biopsies in the patients described by Lerch et al. [1] and Thornburg et al. [2] revealed a nonspecific, hypersensitivity pneumonitis (compatible with toxic drug-induced damage). Immunosuppressive therapy with steroids induced a rapid relief of all symptoms in all 3 cases. Infectious cause of the pulmonary infiltrates could be excluded by br...

Ventilator associated pneumonia is a common and costly complication in critically ill and injured surgical patients. The diagnosis of pneumonia remains problematic and non-specific. Using clinical criteria, a diagnosis of pneumonia is typically not made until an infection is well established. Semi-quantitative cultures of endotracheal aspirate and broncho-alveolar lavage are employed to improve...

STANDARDIZATION OF BRONCHOALVEOLAR LAVAGE ASPIRATION TECHNIQUES TO OPTIMIZE DIAGNOSTIC YIELD OF CANINE LOWER RESPIRATORY TRACT SAMPLES Katharine Sarah Woods Advisor: University of Guelph, 2013 Dr. Alice Defarges Bronchoalveolar lavage (BAL) is a minimally invasive technique utilized in human and veterinary medicine to sample the lower generation bronchi and alveolar spaces. The basic technique ...

BACKGROUND The hallmark of humoral rejection is the presence of subendothelial C4d in the allograft. A simultaneous determination of vascular C4d with soluble C4d in broncho-alveolar lavage fluid (BAL) and circulating anti-human leukocyte antigen (HLA) antibodies (HLA-Ab) has not been reported in lung transplantation. METHODS Forty-two consecutive lung-transplant patients were included in thi...

One year after the occurrence of the first case of infection by the Middle East Respiratory Syndrome coronavirus (MERS-CoV) there is no clear consensus on the best treatment to propose. The World Health Organization, as well as several other national agencies, are still working on different clinical approaches to implement the most relevant treatment in MERS-CoV infection. We compared innate an...

Noninfectious lung injury is common after allogeneic bone marrow transplantation (BMT), but its association with acute graft-versus-host disease (GVHD) is unclear. Using a murine BMT system where donor and host differ by multiple minor histocompatibility (H) antigens, we investigated the nature of lung injury and its relationship both to systemic GVHD and host-reactive donor T cells. Lethally i...

Moxalactam is a new synthetic oxa-beta-lactam antibiotic with a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. It has proven clinical efficacy in pneumonia caused by a variety of infecting organisms. Therapeutic concentrations of moxalactam are achieved in most body tissues and fluids, including pleural fluid and sputum. However, assessment of...

Interstitial lung diseases often are accompanied by histopathologic evidence of alveolar type 2 cell alterations. In the alveolar milieu, the surfactant-specific protein A (SP-A) is a secretory product of alveolar type 2 cells. Therefore, we measured SP-A levels in bronchoalveolar lavage (BAL) fluids from patients with untreated sarcoidosis (n=35) and hypersensitivity pneumonitis (HP [n=10]) an...

based on our knowledge, there have been no studies about the effect of age, sex, lobe and slaughtering stress on cellular distribution of bronchoalveolar lavage fluids in calves and cattle in iran. objectives: the main purpose of this study was to compare the cell distribution pattern of bronchial alveolar lavage fluids in calves and cattle in terms of age, sex, type of lung lobes and the stres...