subnormal responses found in patients given interriittent COT ticosteroid therapy by Malone et al. (1970). This finding, together with the satisfactory clinical response in these patients with severe disease, suggests that a therapeutic trial of depot tetracosactrin in a dose of 0-5 mg twice weekly should be considered for the control of disease requiring steroid therapy over a prolonged period...

The number of atopic patients presenting only chronic non-productive cough appears to be increasing. This study was conducted to confirm the existence of non-asthmatic cough associated with atopy. We prospectively examined atopic findings, therapeutic effects of inhaled procaterol, azelastin, and/or glucocorticoids, improvement of FEV1 by bronchodilator therapy and bronchial responsiveness to m...

We examined the bronchodilator responses to inhalation of salbutamol (200 micrograms) and of ipratropium bromide (40 micrograms) in the morning and in the afternoon before and during a course of oral prednisolone (40 mg daily) in 15 patients with chronic, partly reversible airflow obstruction. Bronchodilatation was assessed by measuring serial peak expiratory flow rates (PEFR) for six hours aft...

Bronchodilator therapy is the first step in improving dyspnoea and exercise endurance in patients with COPD. Recent studies have challenged the long-held view that airway obstruction in COPD is irreversible. We now know that even in the setting of minor or no change in traditional spirometry, bronchodilator therapy is associated with consistent, and often impressive, reduction in lung hyperinfl...