BACKGROUND A retrospective case-control study was undertaken to examine the spatial risk factors for human brucellosis in Kampala, Uganda. METHODS Information on age, sex and month of diagnosis was derived from records from plate agglutination tests undertaken at Mulago Hospital, Kampala. Information on Parishes (LC2s) where patients reside was sourced from the outpatient registration book. I...

Brucellosis is the most widespread zoonosis in the world. The disease is endemic in countries bordering the Mediterranean [1–3]. It is a multisystem disease that may present with a broad spectrum of clinical manifestations and complications. Neurologic manifestations of brucellosis are rare, occurring in 3%–5% of patients with systemic brucellosis [4]. Nervous system manifestations are very het...

Brucella canis is the causative agent of canine brucellosis and facultative intracellular pathogen. The diagnosis of canine brucellosis is based on bacteriological examination and serological methods including agglutination and gel diffusion tests. In this study, crude antigens were extracted from B. canis using hot saline, coated on to latex beads and their usefulness in the serological diagno...

This study aimed to establish an accurate and sensitive polymerase chain reaction (PCR) technique for the diagnosis of active human brucellosis in Egypt. We failed to extract Brucella DNA with a commercial kit, but an extraction kit designed in-house using 2 sets of primers [B4/B5 (223 bp) and JPF/JPR (193 bp)] was successful and more economical. The technique showed high sensitivity, specifici...

Introduction: Brucellar epididymo-orchitis (BEO) is the most common variant of genitourinary brucellosis and is encountered in 2 to 20% of patients with brucellosis. This report details clinical and laboratory features, diagnostic evaluations, treatment modalities, and final outcomes for 14 patients with brucellar epididymo-orchitis. Material and Methods: In this retrospective study, we describ...

Brucella canis is considered a rare cause of human brucellosis. The clinical importance of this infection may have been underestimated so far because of difficulties with presumptive diagnosis. The case described here presented symptoms compatible with brucellosis but the routine tests using Brucella abortus antigen were negative. The infection would have remained undiagnosed if culture had not...

BACKGROUND The objectives of this systematic review, commissioned by WHO, were to assess the frequency and severity of clinical manifestations of human brucellosis, in view of specifying a disability weight for a DALY calculation. METHODS/PRINCIPAL FINDINGS Thirty three databases were searched, with 2,385 articles published between January 1990-June 2010 identified as relating to human brucel...

OBJECTIVE To investigate whether visual evoked potentials (VEPs) are valuable for distinguishing between brucellosis with or without neurological involvement. METHODS A total of 23 patients who were admitted to the Department of Infectious Diseases and Microbiology, and Neurology, Ministry of Health Ankara Education and Research Hospital, Ankara, Turkey between December 2004 and August 2005 w...