نتایج جستجو برای: brugada syndrome
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Background: Mutations in the cardiac sodium channel, SCN5A, have been associated with one type of long-QT syndrome, with isolated cardiac conduction defects and Brugada syndrome. The sodium channelopathies exhibit marked variation in clinical phenotypes. The mechanisms underlying the phenotypical diversity, however, remain unknown. Exonic SCN5A mutations can be detected in 20% of Brugada syndro...
Brugada, Pedro Brugada, Domenico Corrado, Richard N.W. Hauer, Robert S. Kass, Arthur A.M. Wilde, Charles Antzelevitch, Martin Borggrefe, Josep Brugada, Ramón Proposed Diagnostic Criteria for the Brugada Syndrome : Consensus Report ISSN: 1524-4539 Copyright © 2002 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart A...
SCN5A gene mutations can lead to ion channel defects which can cause cardiac conduction disturbances. In the presence of specific ECG characteristics, this mutation is called Brugada syndrome. Many drugs are associated with adverse events, making anesthesia in patients with SCN5A gene mutations or Brugada syndrome challenging. In this case report, we describe a pregnant patient with this mutati...
OBJECTIVES We sought to demonstrate the mode of spontaneous onset of ventricular fibrillation (VF) in patients with Brugada syndrome. BACKGROUND The electrophysiologic mechanisms of VF in Brugada syndrome have not been fully investigated. METHODS Nineteen patients (all male, mean age 47 +/- 12 years) with Brugada syndrome were treated with an implantable cardioverter defibrillator (ICD). Th...
There are few reports of electrocardiogram (ECG) changes of conus branch occlusion. A conus branch artery supply to the outflow tract of right ventricle. A conus branch artery is considered as the substrate of Brugada syndrome. We report a case of conus branch occlusion during angioplasty with ST segment elevation in V1-3 like Brugada syndrome ECG. We need to bear in mind that this ECG change m...
The Brugada syndrome is characterized by a ST-segment elevation in the right precordial leads associated with right bundle branch block (RBBB) pattern and a propensity for life-threatening ventricular arrhythmias in the absence of structural heart disease. 1 Mutations in a cardiac sodium channel gene have been linked to this syndrome 2. The mechanism underlying the RBBB and ST-segment elevation...
BACKGROUND Brugada syndrome is an arrhythmogenic disease characterized by an ECG pattern of ST-segment elevation in the right precordial leads and augmented risk of sudden cardiac death. Little is known about the clinical presentation and prognosis of this disease in children. METHODS AND RESULTS Thirty children affected by Brugada syndrome who were <16 years of age (mean, 8+/-4 years) were i...
The diagnosis of Brugada syndrome, or right bundle-branch block with an elevated ST segment and negative T waves in V1-3, is obscured by the transitory normalization of the electrocardiogram, which can be unmasked by administering sodium-channel blockers. It has been recently reported that the condition can be underdiagnosed if only conventional precordial leads are used. We present the cases o...
BACKGROUND Class IC antiarrhythmic agents may induce acquired forms of Brugada Syndrome. We have identified a novel mutation in SCN5A, the gene that encodes the α-subunit of the human cardiac sodium channel (hNav1.5), in a patient who exhibited Brugada- type ECG changes during pharmacotherapy of atrial arrhythmias. OBJECTIVE To assess whether the novel mutation p.V1328M can cause drug induced...
According to the International Classification of Disease (ICD-9), sudden death (SD) is defined as natural and unexpected death, heralded by an abrupt loss of consciousness within 24 h of the onset of acute symptoms. A specific variation of SD has been observed in Southeast Asians. Baron et al. reported 51cases of sudden unexplained nocturnal death (SUND) among Southeast Asian refugees to the Ce...
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